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1-Hexylcarbamoyl-5-fluorouracil (HCFU) was administered orally to 63 patients with hepatocellular carcinoma (HCC) at a daily dose of 200 to 600 mg. Twenty three of those patients who received HCFU over 4 weeks without any other therapies were studied for its antitumor effect. Eighteen patients were evaluated for tumor size. The results showed a response rate of 16.7% (3/18) based on the criteria of Koyama et al. Patients with minute hepatoma had an especially good response; the response rate being 40% (2/5), or 60% (3/5) including minor response. Tests showed no aggravation of liver function. HCFU was considered to be useful in the treatment of HCC. However, unexpected adverse neurological effects were encountered in 6 patients. They began with slurred speech, bradypragia and gait disturbance, and finally progressed to unconsciousness in 4 out of 6 patients, in which the clinical picture resembled hepatic encephalopathy. Though reversible, these symptoms necessitate immediate withdrawal of HCFU therapy.
K Shiraishi, and
Y Kubo, and
Y Majima, and
K Sato, and
T Sakemi, and
T Sakai, and
K Hirai, and
F Ninomiya, and
M Abe, and
K Tanikawa
August 1989,
European journal of cancer & clinical oncology,
K Shiraishi, and
Y Kubo, and
Y Majima, and
K Sato, and
T Sakemi, and
T Sakai, and
K Hirai, and
F Ninomiya, and
M Abe, and
K Tanikawa
October 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
K Shiraishi, and
Y Kubo, and
Y Majima, and
K Sato, and
T Sakemi, and
T Sakai, and
K Hirai, and
F Ninomiya, and
M Abe, and
K Tanikawa
June 1981,
Cancer treatment reviews,
K Shiraishi, and
Y Kubo, and
Y Majima, and
K Sato, and
T Sakemi, and
T Sakai, and
K Hirai, and
F Ninomiya, and
M Abe, and
K Tanikawa
October 1985,
Nihon Gan Chiryo Gakkai shi,
K Shiraishi, and
Y Kubo, and
Y Majima, and
K Sato, and
T Sakemi, and
T Sakai, and
K Hirai, and
F Ninomiya, and
M Abe, and
K Tanikawa
January 1980,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
K Shiraishi, and
Y Kubo, and
Y Majima, and
K Sato, and
T Sakemi, and
T Sakai, and
K Hirai, and
F Ninomiya, and
M Abe, and
K Tanikawa
January 1982,
Gan to kagaku ryoho. Cancer & chemotherapy,
K Shiraishi, and
Y Kubo, and
Y Majima, and
K Sato, and
T Sakemi, and
T Sakai, and
K Hirai, and
F Ninomiya, and
M Abe, and
K Tanikawa
May 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
K Shiraishi, and
Y Kubo, and
Y Majima, and
K Sato, and
T Sakemi, and
T Sakai, and
K Hirai, and
F Ninomiya, and
M Abe, and
K Tanikawa
January 1980,
Cancer treatment reports,
K Shiraishi, and
Y Kubo, and
Y Majima, and
K Sato, and
T Sakemi, and
T Sakai, and
K Hirai, and
F Ninomiya, and
M Abe, and
K Tanikawa
February 1989,
Gan to kagaku ryoho. Cancer & chemotherapy,
K Shiraishi, and
Y Kubo, and
Y Majima, and
K Sato, and
T Sakemi, and
T Sakai, and
K Hirai, and
F Ninomiya, and
M Abe, and
K Tanikawa
January 1981,
Xenobiotica; the fate of foreign compounds in biological systems,
