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We studied the effect of lymphocytosis promoting factor (LPF), derived from the supernatant fluid of a culture of phase I Bordetella pertussis strain Tohama, on human lymphocyte proliferation. LPF was a potent mitogen for human mononuclear cells, specifically T cells. LPF failed to induce cytoplasmic immunoglobulin production by B cells. Removal of the monocytes from the T cell fraction diminished responses to LPF, but the response could be restored completely by the addition of 5.0% monocytes. These results suggest that LPF-induced cell proliferation is at least partially dependent on monocytes. In contrast to PHA, LPF stimulated T gamma cells to a greater extent than non-T gamma cells, but the magnitude of the T gamma or non-T gamma cell response was less than that of T cells, indicating that synergistic interactions between T gamma and non-T gamma cells are required for maximal response.
H Kashiwa, and
S Hyodo, and
T Kishi, and
T Karakawa, and
E Kittaka, and
T Suzawa, and
T Sakano, and
T Usui
September 1977,
The Journal of clinical investigation,
H Kashiwa, and
S Hyodo, and
T Kishi, and
T Karakawa, and
E Kittaka, and
T Suzawa, and
T Sakano, and
T Usui
June 1982,
Infection and immunity,
H Kashiwa, and
S Hyodo, and
T Kishi, and
T Karakawa, and
E Kittaka, and
T Suzawa, and
T Sakano, and
T Usui
May 1986,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
H Kashiwa, and
S Hyodo, and
T Kishi, and
T Karakawa, and
E Kittaka, and
T Suzawa, and
T Sakano, and
T Usui
March 1973,
Infection and immunity,
H Kashiwa, and
S Hyodo, and
T Kishi, and
T Karakawa, and
E Kittaka, and
T Suzawa, and
T Sakano, and
T Usui
May 1983,
Infection and immunity,
H Kashiwa, and
S Hyodo, and
T Kishi, and
T Karakawa, and
E Kittaka, and
T Suzawa, and
T Sakano, and
T Usui
December 1978,
Clinical and experimental immunology,
H Kashiwa, and
S Hyodo, and
T Kishi, and
T Karakawa, and
E Kittaka, and
T Suzawa, and
T Sakano, and
T Usui
August 1977,
The Journal of infectious diseases,
H Kashiwa, and
S Hyodo, and
T Kishi, and
T Karakawa, and
E Kittaka, and
T Suzawa, and
T Sakano, and
T Usui
April 1984,
Infection and immunity,
H Kashiwa, and
S Hyodo, and
T Kishi, and
T Karakawa, and
E Kittaka, and
T Suzawa, and
T Sakano, and
T Usui
October 1968,
Japanese journal of medical science & biology,
H Kashiwa, and
S Hyodo, and
T Kishi, and
T Karakawa, and
E Kittaka, and
T Suzawa, and
T Sakano, and
T Usui
June 1976,
The Journal of experimental medicine,
