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The effect of acute and chronic crossover administration of ranitidine and cimetidine on gastric emptying was studied in healthy volunteers and in duodenal ulcer patients, respectively. In the first series of experiments, intravenous ranitidine (50 mg) significantly (p less than 0.05) delayed emptying of both solids and liquids, whereas cimetidine (300 mg i.v.) was totally ineffective. In the second set of experiments, neither ranitidine (150 mg bd orally for two weeks) nor cimetidine (400 mg bd) significantly modified emptying rate. These results, therefore, suggest that only high blood levels of ranitidine, as elicited by intravenous administration, are able to affect gastric emptying. On the contrary, at steady state levels elicited by conventional therapeutic doses, no effect on gastric emptying is evident.
R Corinaldesi, and
C Scarpignato, and
A Galassi, and
V Stanghellini, and
R Calamelli, and
G Bertaccini, and
L Barbara
April 1982,
Agents and actions,
R Corinaldesi, and
C Scarpignato, and
A Galassi, and
V Stanghellini, and
R Calamelli, and
G Bertaccini, and
L Barbara
January 1993,
Archives internationales de physiologie, de biochimie et de biophysique,
R Corinaldesi, and
C Scarpignato, and
A Galassi, and
V Stanghellini, and
R Calamelli, and
G Bertaccini, and
L Barbara
January 1978,
Digestion,
R Corinaldesi, and
C Scarpignato, and
A Galassi, and
V Stanghellini, and
R Calamelli, and
G Bertaccini, and
L Barbara
March 1988,
Gut,
R Corinaldesi, and
C Scarpignato, and
A Galassi, and
V Stanghellini, and
R Calamelli, and
G Bertaccini, and
L Barbara
April 1988,
Journal of clinical gastroenterology,
R Corinaldesi, and
C Scarpignato, and
A Galassi, and
V Stanghellini, and
R Calamelli, and
G Bertaccini, and
L Barbara
February 1982,
British journal of clinical pharmacology,
R Corinaldesi, and
C Scarpignato, and
A Galassi, and
V Stanghellini, and
R Calamelli, and
G Bertaccini, and
L Barbara
October 1987,
Alimentary pharmacology & therapeutics,
R Corinaldesi, and
C Scarpignato, and
A Galassi, and
V Stanghellini, and
R Calamelli, and
G Bertaccini, and
L Barbara
December 1989,
Regulatory peptides,
R Corinaldesi, and
C Scarpignato, and
A Galassi, and
V Stanghellini, and
R Calamelli, and
G Bertaccini, and
L Barbara
December 1985,
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons,
R Corinaldesi, and
C Scarpignato, and
A Galassi, and
V Stanghellini, and
R Calamelli, and
G Bertaccini, and
L Barbara
December 1994,
British journal of clinical pharmacology,
