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The pharmacokinetics of cefotaxime were studied in 13 patients on haemodialysis or continuous ambulatory peritoneal dialysis (CAPD). One gram of cefotaxime was administered intravenously or intraperitoneally. In the haemodialysis patients, the serum concentration after 4h was 9.4 mg/l and the T1/2 was 1.31 h. The 6-h value and T1/2 in the CAPD (intravenous) patients were 4.5 mg/l and 1.59 hours, while the peak value in the dialysate was 11.6 mg/l. In the CAPD (intraperitoneal) patients, the cefotaxime concentration in the dialysate was 157 mg/l after 6 h and the peak value in the serum was 9.1 mg/l. Since cefotaxime is easily removed from the blood by both the haemodialysis and CAPD methods, accumulation of the drug in patients undergoing dialysis is unlikely to occur.
H Hasegawa, and
A Imada, and
A Horiuchi, and
Y Nishii, and
M Fukushima, and
E Kurokawa
January 1990,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
H Hasegawa, and
A Imada, and
A Horiuchi, and
Y Nishii, and
M Fukushima, and
E Kurokawa
July 1992,
Antimicrobial agents and chemotherapy,
H Hasegawa, and
A Imada, and
A Horiuchi, and
Y Nishii, and
M Fukushima, and
E Kurokawa
January 2003,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
H Hasegawa, and
A Imada, and
A Horiuchi, and
Y Nishii, and
M Fukushima, and
E Kurokawa
April 1981,
Antimicrobial agents and chemotherapy,
H Hasegawa, and
A Imada, and
A Horiuchi, and
Y Nishii, and
M Fukushima, and
E Kurokawa
May 1984,
Antimicrobial agents and chemotherapy,
H Hasegawa, and
A Imada, and
A Horiuchi, and
Y Nishii, and
M Fukushima, and
E Kurokawa
March 1984,
Antimicrobial agents and chemotherapy,
H Hasegawa, and
A Imada, and
A Horiuchi, and
Y Nishii, and
M Fukushima, and
E Kurokawa
August 1983,
Antimicrobial agents and chemotherapy,
H Hasegawa, and
A Imada, and
A Horiuchi, and
Y Nishii, and
M Fukushima, and
E Kurokawa
June 1990,
Clinical pharmacokinetics,
H Hasegawa, and
A Imada, and
A Horiuchi, and
Y Nishii, and
M Fukushima, and
E Kurokawa
January 2009,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
H Hasegawa, and
A Imada, and
A Horiuchi, and
Y Nishii, and
M Fukushima, and
E Kurokawa
May 1988,
Journal of clinical pharmacology,
