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The role of prophylactic cefotaxime and a combination of ampicillin and tinidazole was assessed in 201 patients undergoing hysterectomy. One hundred and twenty-five patients were evaluated in the abdominal hysterectomy group and 46 patients completed the protocol after vaginal hysterectomy. Patients were allocated randomly to receive either (1) no prophylactic antibiotic, (2) cefotaxime peroperatively for 24 h or (3) ampicillin/tinidazole peroperatively for 24 h. Both cefotaxime and ampicillin/tinidazole reduced the septic complication rate in abdominal and vaginal hysterectomy. Efficacy was most evident in reducing early urinary infections after abdominal hysterectomy (0.001 less than P less than 0.01). Cefotaxime and ampicillin/tinidazole were equally effective and no significant side-effects were demonstrated. Cefotaxime is recommended as a safe and effective agent for hysterectomy prophylaxis.
P J McDonald, and
T Sanders, and
G Higgins, and
L Finlay-Jones, and
M Hakendorf, and
J Turnidge, and
W Jones
November 2008,
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia,
P J McDonald, and
T Sanders, and
G Higgins, and
L Finlay-Jones, and
M Hakendorf, and
J Turnidge, and
W Jones
August 1993,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
P J McDonald, and
T Sanders, and
G Higgins, and
L Finlay-Jones, and
M Hakendorf, and
J Turnidge, and
W Jones
February 1985,
The Australian & New Zealand journal of obstetrics & gynaecology,
P J McDonald, and
T Sanders, and
G Higgins, and
L Finlay-Jones, and
M Hakendorf, and
J Turnidge, and
W Jones
August 1993,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
P J McDonald, and
T Sanders, and
G Higgins, and
L Finlay-Jones, and
M Hakendorf, and
J Turnidge, and
W Jones
January 1986,
Acta obstetricia et gynecologica Scandinavica,
P J McDonald, and
T Sanders, and
G Higgins, and
L Finlay-Jones, and
M Hakendorf, and
J Turnidge, and
W Jones
January 1980,
British journal of obstetrics and gynaecology,
P J McDonald, and
T Sanders, and
G Higgins, and
L Finlay-Jones, and
M Hakendorf, and
J Turnidge, and
W Jones
June 1994,
Minerva ginecologica,
P J McDonald, and
T Sanders, and
G Higgins, and
L Finlay-Jones, and
M Hakendorf, and
J Turnidge, and
W Jones
April 1987,
British journal of urology,
P J McDonald, and
T Sanders, and
G Higgins, and
L Finlay-Jones, and
M Hakendorf, and
J Turnidge, and
W Jones
December 1976,
Dimensions in health service,
P J McDonald, and
T Sanders, and
G Higgins, and
L Finlay-Jones, and
M Hakendorf, and
J Turnidge, and
W Jones
February 1986,
Danish medical bulletin,
