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To determine the role of antibodies in establishing Herpes simplex virus (HSV) latency, immunosuppressed Swiss mice were experimentally infected in the right hind footpad with a HSV-1 x HSV-2 recombinant (C6D) with low virulence. Immunosuppression was induced by repeated intraperitoneal inoculations of Cyclophosphamide (CY) and the production of antibodies to C6D in immunosuppressed animals was monitored by Enzyme Linked Immunosorbent Assay (ELISA). Within 21 days after inoculation, C6D was able to establish a latent infection of lumbosacral spinal ganglia in both normal and CY-treated immunosuppressed animals. The data presented indicate that detectable production of antibodies is not necessary to induce HSV latency in spinal ganglia.
A Rotula, and
D Di Luca, and
G Gerna, and
R Manservigi, and
M Tognon, and
E Cassai
December 2003,
Expert reviews in molecular medicine,
A Rotula, and
D Di Luca, and
G Gerna, and
R Manservigi, and
M Tognon, and
E Cassai
January 1989,
Lancet (London, England),
A Rotula, and
D Di Luca, and
G Gerna, and
R Manservigi, and
M Tognon, and
E Cassai
January 1984,
Clinics in dermatology,
A Rotula, and
D Di Luca, and
G Gerna, and
R Manservigi, and
M Tognon, and
E Cassai
January 1977,
Duodecim; laaketieteellinen aikakauskirja,
A Rotula, and
D Di Luca, and
G Gerna, and
R Manservigi, and
M Tognon, and
E Cassai
February 1983,
Infection and immunity,
A Rotula, and
D Di Luca, and
G Gerna, and
R Manservigi, and
M Tognon, and
E Cassai
January 1985,
Antiviral research,
A Rotula, and
D Di Luca, and
G Gerna, and
R Manservigi, and
M Tognon, and
E Cassai
January 1992,
Progress in medical virology. Fortschritte der medizinischen Virusforschung. Progres en virologie medicale,
A Rotula, and
D Di Luca, and
G Gerna, and
R Manservigi, and
M Tognon, and
E Cassai
May 2024,
Viruses,
A Rotula, and
D Di Luca, and
G Gerna, and
R Manservigi, and
M Tognon, and
E Cassai
April 1978,
British medical journal,
A Rotula, and
D Di Luca, and
G Gerna, and
R Manservigi, and
M Tognon, and
E Cassai
August 1990,
Nippon Ganka Gakkai zasshi,
