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Premature rabbit neonates, delivered on day 28 of gestation, were treated with a single dose of dibuturyladenosine-3':5'-cyclic monophosphate (cyclic AMP), 300 mg/kg, immediately after delivery, saline-injected litter-mates serving as controls. All animals were kept in body plethysmographs and ventilated artificially with 100% oxygen for 1 h, with a maximal tidal volume of 10 ml/kg body weight. Lung-thorax compliance was significantly improved in animals treated with cyclic AMP, both 30 and 60 min after onset of ventilation (0.92 +/- 0.09 vs. 0.59 +/- 0.08 ml/cm H2O.kg and 0.96 +/- 0.09 vs. 0.53 +/- 0.08, p less than 0.005), but there was no improvement in alveolar air expansion, evaluated histologically. Phosphatidylglycerol was absent in alveolar wash from all control animals, but present in 3 of the 8 pooled samples from the animals treated with cyclic AMP; this difference was not statistically significant, however.
E V Cosmi, and
B Lachmann, and
G Grossmann, and
C Marzano, and
C Orezzi, and
C Saitto, and
B Robertson
May 1981,
Pediatric research,
E V Cosmi, and
B Lachmann, and
G Grossmann, and
C Marzano, and
C Orezzi, and
C Saitto, and
B Robertson
November 1972,
Biochemical pharmacology,
E V Cosmi, and
B Lachmann, and
G Grossmann, and
C Marzano, and
C Orezzi, and
C Saitto, and
B Robertson
October 1971,
Biochimica et biophysica acta,
E V Cosmi, and
B Lachmann, and
G Grossmann, and
C Marzano, and
C Orezzi, and
C Saitto, and
B Robertson
July 1982,
Toxicology and applied pharmacology,
E V Cosmi, and
B Lachmann, and
G Grossmann, and
C Marzano, and
C Orezzi, and
C Saitto, and
B Robertson
April 1977,
The Journal of biological chemistry,
E V Cosmi, and
B Lachmann, and
G Grossmann, and
C Marzano, and
C Orezzi, and
C Saitto, and
B Robertson
August 1979,
Scandinavian journal of respiratory diseases,
E V Cosmi, and
B Lachmann, and
G Grossmann, and
C Marzano, and
C Orezzi, and
C Saitto, and
B Robertson
January 1971,
Methods of biochemical analysis,
E V Cosmi, and
B Lachmann, and
G Grossmann, and
C Marzano, and
C Orezzi, and
C Saitto, and
B Robertson
March 1977,
The Journal of clinical endocrinology and metabolism,
E V Cosmi, and
B Lachmann, and
G Grossmann, and
C Marzano, and
C Orezzi, and
C Saitto, and
B Robertson
February 1983,
Thrombosis and haemostasis,
E V Cosmi, and
B Lachmann, and
G Grossmann, and
C Marzano, and
C Orezzi, and
C Saitto, and
B Robertson
January 1982,
Voprosy meditsinskoi khimii,
