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The beta-adrenoreceptor density in intact lymphocytes of peripheral blood of normotensive and hypertensive adults was measured by the radioligand binding technique with the use of 3H-dihydroalprenolol. The density of beta-adrenoreceptors was found to be higher in lymphocytes of hypertensive subjects while the number of the receptors was equal to 2076 +/- 208 and 1461 +/- 175 receptors per cell, respectively, in hypertensive and normotensive subjects. The dissociation constants in both cases varied from 0.4 to 1.8 nM. Probably, the decreased responses to the adrenergic agents in hypertensive subjects are not connected with the decreased number of beta-adrenoreceptors and may be due to alterations in postreceptor events.
T L Krasnikova, and
V A Radiukhin, and
O B Il'inskiĭ, and
I K Shkhvatsabaia, and
E V Parfenova
January 1984,
International journal of clinical pharmacology research,
T L Krasnikova, and
V A Radiukhin, and
O B Il'inskiĭ, and
I K Shkhvatsabaia, and
E V Parfenova
October 1979,
Psychiatry research,
T L Krasnikova, and
V A Radiukhin, and
O B Il'inskiĭ, and
I K Shkhvatsabaia, and
E V Parfenova
February 1986,
Nihon Kyobu Shikkan Gakkai zasshi,
T L Krasnikova, and
V A Radiukhin, and
O B Il'inskiĭ, and
I K Shkhvatsabaia, and
E V Parfenova
December 1979,
Clinical and experimental immunology,
T L Krasnikova, and
V A Radiukhin, and
O B Il'inskiĭ, and
I K Shkhvatsabaia, and
E V Parfenova
January 1980,
The Journal of allergy and clinical immunology,
T L Krasnikova, and
V A Radiukhin, and
O B Il'inskiĭ, and
I K Shkhvatsabaia, and
E V Parfenova
May 1981,
Journal of gerontology,
T L Krasnikova, and
V A Radiukhin, and
O B Il'inskiĭ, and
I K Shkhvatsabaia, and
E V Parfenova
September 1990,
Medicina clinica,
T L Krasnikova, and
V A Radiukhin, and
O B Il'inskiĭ, and
I K Shkhvatsabaia, and
E V Parfenova
December 1987,
Activitas nervosa superior,
T L Krasnikova, and
V A Radiukhin, and
O B Il'inskiĭ, and
I K Shkhvatsabaia, and
E V Parfenova
January 1994,
Pneumonologia i alergologia polska,
T L Krasnikova, and
V A Radiukhin, and
O B Il'inskiĭ, and
I K Shkhvatsabaia, and
E V Parfenova
December 1987,
European journal of clinical investigation,
