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The preparation of a feline Coombs serum (rabbit antifeline gamma globulin) is described. The direct antiglobulin test using this serum was performed on 20 anemic and 20 healthy control cats. Red cell membrane antibodies were detected in cats with feline leukemia virus infection and in others with inflammatory and neoplastic diseases. A low titre of cold agglutinating antibody was present in a high proportion of the control cats. Positive direct antiglobulin tests were noted in cats without overt hemolytic disease. It was concluded that the direct antiglobulin test in anemic cats has certain diagnostic limitations. A positive reaction should be interpreted cautiously especially when there is no clinical or laboratory evidence to support a diagnosis of autoimmune hemolytic anemia.
J K Dunn, and
G P Searcy, and
V M Hirsch
November 1979,
Veterinary immunology and immunopathology,
J K Dunn, and
G P Searcy, and
V M Hirsch
January 2002,
Immunohematology,
J K Dunn, and
G P Searcy, and
V M Hirsch
June 1978,
British journal of haematology,
J K Dunn, and
G P Searcy, and
V M Hirsch
January 1994,
Infection,
J K Dunn, and
G P Searcy, and
V M Hirsch
January 1999,
Vox sanguinis,
J K Dunn, and
G P Searcy, and
V M Hirsch
January 1990,
American journal of hematology,
J K Dunn, and
G P Searcy, and
V M Hirsch
February 1980,
Vox sanguinis,
J K Dunn, and
G P Searcy, and
V M Hirsch
August 2018,
Transfusion,
J K Dunn, and
G P Searcy, and
V M Hirsch
January 1983,
Clinical and laboratory haematology,
J K Dunn, and
G P Searcy, and
V M Hirsch
February 2017,
Pediatric hematology and oncology,
