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The effects of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) on the formation in vitro of aflatoxin Q1 and aflatoxin M1 from aflatoxin B1 by rat-liver microsomes were investigated. AFB1 metabolism by hepatic microsomes from PBB- and PCB-treated rats resulted in 16- and 30-fold increases, respectively, in levels of aflatoxin M1. The enhanced formation of aflatoxin M1 did not correlate with PBB and PCB stimulation of benzo[a]pyrene hydroxylase (AHH) activity. Studies in vivo clearly demonstrated enhanced secretion of aflatoxin M1 by female lactating rats with prior exposure to PCBs. PCB pretreatment enhanced the activity of mammary as well as hepatic tissue microsomal preparations in converting aflatoxin B1 to aflatoxin M1. Our findings indicate that PCB exposure increases the production of aflatoxin M1 in vitro and also increases the levels of aflatoxin M1 released into the milk.
E C Shepherd, and
T D Phillips, and
T R Irvin, and
S H Safe, and
L W Robertson
April 1985,
Applied and environmental microbiology,
E C Shepherd, and
T D Phillips, and
T R Irvin, and
S H Safe, and
L W Robertson
September 1976,
Research communications in chemical pathology and pharmacology,
E C Shepherd, and
T D Phillips, and
T R Irvin, and
S H Safe, and
L W Robertson
July 1974,
Life sciences,
E C Shepherd, and
T D Phillips, and
T R Irvin, and
S H Safe, and
L W Robertson
March 1982,
Research communications in chemical pathology and pharmacology,
E C Shepherd, and
T D Phillips, and
T R Irvin, and
S H Safe, and
L W Robertson
February 1982,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
E C Shepherd, and
T D Phillips, and
T R Irvin, and
S H Safe, and
L W Robertson
February 2024,
Toxicon : official journal of the International Society on Toxinology,
E C Shepherd, and
T D Phillips, and
T R Irvin, and
S H Safe, and
L W Robertson
January 1984,
Journal of toxicology and environmental health,
E C Shepherd, and
T D Phillips, and
T R Irvin, and
S H Safe, and
L W Robertson
April 1987,
Cancer research,
E C Shepherd, and
T D Phillips, and
T R Irvin, and
S H Safe, and
L W Robertson
November 1980,
Chemico-biological interactions,
E C Shepherd, and
T D Phillips, and
T R Irvin, and
S H Safe, and
L W Robertson
January 1976,
Journal of agricultural and food chemistry,
