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Retinoic acid, dexamethasone and prednisolone were evaluated for their effects on Epstein-Barr virus (EBV)-induced nuclear antigen (EBNA), DNA synthesis and transformation of human thymus-independent, B lymphocytes. It was found that continuous treatment of target cells with these agents completely inhibited EBV-induced transformation events. However, discontinuous treatment of the virus-infected cultures with these agents resulted in the recovery of DNA synthesis, and the appearance of EBNA and transformation. When the cells were treated with these agents 8 days after the virus infection, the inhibitors had no effect. These results show that only continuous treatment with these agents inhibited EBV-mediated transformation; these inhibitors had no effect once the EBNA and EBV-induced DNA synthesis were initiated in target lymphocytes.
S K Sundar, and
P H Levine, and
D V Ablashi, and
J Menezes
February 1976,
Infection and immunity,
S K Sundar, and
P H Levine, and
D V Ablashi, and
J Menezes
April 1976,
Nature,
S K Sundar, and
P H Levine, and
D V Ablashi, and
J Menezes
January 1980,
Cold Spring Harbor symposia on quantitative biology,
S K Sundar, and
P H Levine, and
D V Ablashi, and
J Menezes
January 1982,
Progress in medical virology. Fortschritte der medizinischen Virusforschung. Progres en virologie medicale,
S K Sundar, and
P H Levine, and
D V Ablashi, and
J Menezes
January 1987,
Journal of virology,
S K Sundar, and
P H Levine, and
D V Ablashi, and
J Menezes
December 1984,
Proceedings of the National Academy of Sciences of the United States of America,
S K Sundar, and
P H Levine, and
D V Ablashi, and
J Menezes
February 1982,
Journal of virology,
S K Sundar, and
P H Levine, and
D V Ablashi, and
J Menezes
April 1988,
Immunology and cell biology,
S K Sundar, and
P H Levine, and
D V Ablashi, and
J Menezes
January 1982,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
S K Sundar, and
P H Levine, and
D V Ablashi, and
J Menezes
July 1981,
Virology,
