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The inhibitory action of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on the replication of human cytomegalovirus was studied. Three laboratory strains (AD-169, Towne, and Davis) and three early passage (less than 10) clinical isolates were all inhibited in yield inhibition assays. In cultures infected with AD-169, virus yields could be inhibited if the drug was added as late as 3 days after the replication cycle had begun. The effects of the drug were fully reversible during the first 4 days of the viral replication cycle. Viral infectivity and viral DNA synthesis were reduced more than viral protein synthesis. Synergistic antiviral effects were observed with beta-cysteine, and to a lesser extent, with beta-serine recombinant interferons, but only over a narrow range of dose combinations.
L Rasmussen, and
P T Chen, and
J G Mullenax, and
T C Merigan
October 1983,
Antimicrobial agents and chemotherapy,
L Rasmussen, and
P T Chen, and
J G Mullenax, and
T C Merigan
August 1986,
Annals of internal medicine,
L Rasmussen, and
P T Chen, and
J G Mullenax, and
T C Merigan
February 1988,
Transplantation proceedings,
L Rasmussen, and
P T Chen, and
J G Mullenax, and
T C Merigan
April 1986,
Annals of internal medicine,
L Rasmussen, and
P T Chen, and
J G Mullenax, and
T C Merigan
October 1985,
The Journal of infectious diseases,
L Rasmussen, and
P T Chen, and
J G Mullenax, and
T C Merigan
August 1985,
Antimicrobial agents and chemotherapy,
L Rasmussen, and
P T Chen, and
J G Mullenax, and
T C Merigan
August 1989,
Ugeskrift for laeger,
L Rasmussen, and
P T Chen, and
J G Mullenax, and
T C Merigan
June 1988,
Transplantation,
L Rasmussen, and
P T Chen, and
J G Mullenax, and
T C Merigan
June 1987,
The Journal of general virology,
L Rasmussen, and
P T Chen, and
J G Mullenax, and
T C Merigan
February 1987,
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie,
