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In platelets of normal volunteers taking chlorimipramine (50 mg/day) for one week, the saturable uptake of [3H]5HT was fully inhibited at day 8, but returned to control values at day 15. The Bmax of [3H]imipramine binding was decreased by 65% at day 8 and remained significantly below control values at day 15. If the present findings can be extrapolated to other antidepressants, the reported decreases in [3H]imipramine binding in depression may partly reflect residual treatment effects. It cannot be excluded that, in depression, the platelet [3H]imipramine receptor already is down-regulated maximally which would preclude a further down-regulation due to antidepressant drug therapy.
M F Poirier, and
H Loo, and
C Benkelfat, and
D Sechter, and
E Zarifian, and
A M Galzin, and
H Schoemaker, and
A Segonzac, and
S Z Langer
April 1985,
European journal of pharmacology,
M F Poirier, and
H Loo, and
C Benkelfat, and
D Sechter, and
E Zarifian, and
A M Galzin, and
H Schoemaker, and
A Segonzac, and
S Z Langer
July 1986,
European journal of pharmacology,
M F Poirier, and
H Loo, and
C Benkelfat, and
D Sechter, and
E Zarifian, and
A M Galzin, and
H Schoemaker, and
A Segonzac, and
S Z Langer
January 1986,
Clinical neuropharmacology,
M F Poirier, and
H Loo, and
C Benkelfat, and
D Sechter, and
E Zarifian, and
A M Galzin, and
H Schoemaker, and
A Segonzac, and
S Z Langer
June 1990,
European journal of pharmacology,
M F Poirier, and
H Loo, and
C Benkelfat, and
D Sechter, and
E Zarifian, and
A M Galzin, and
H Schoemaker, and
A Segonzac, and
S Z Langer
November 1986,
Psychiatry research,
M F Poirier, and
H Loo, and
C Benkelfat, and
D Sechter, and
E Zarifian, and
A M Galzin, and
H Schoemaker, and
A Segonzac, and
S Z Langer
November 1984,
European journal of pharmacology,
M F Poirier, and
H Loo, and
C Benkelfat, and
D Sechter, and
E Zarifian, and
A M Galzin, and
H Schoemaker, and
A Segonzac, and
S Z Langer
July 1982,
European journal of pharmacology,
M F Poirier, and
H Loo, and
C Benkelfat, and
D Sechter, and
E Zarifian, and
A M Galzin, and
H Schoemaker, and
A Segonzac, and
S Z Langer
January 1990,
Progress in neuro-psychopharmacology & biological psychiatry,
M F Poirier, and
H Loo, and
C Benkelfat, and
D Sechter, and
E Zarifian, and
A M Galzin, and
H Schoemaker, and
A Segonzac, and
S Z Langer
September 1986,
Psychiatry research,
M F Poirier, and
H Loo, and
C Benkelfat, and
D Sechter, and
E Zarifian, and
A M Galzin, and
H Schoemaker, and
A Segonzac, and
S Z Langer
June 1990,
Psychiatry research,
