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Male rats were orally administered an inhibitor of angiotensin-converting enzyme (ACE), N-[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-1-ala-1-pro maleate (enalapril, MK-0421) at dosage levels of 10, 30, and 90 mg/kg X d. After 2-6 wk of dosing, the rats receiving 30 and 90 mg/kg X d produced large numbers of seminal plugs and had lacerated penises due to licking in an attempt to recover urine. Providing 0.9% saline as the source of drinking water prevented this behavior and subsequent lesions. There were no adverse effects on reproductive performance. A subsequent study showed that enalapril at 5 mg/kg X d po and captopril (another ACE inhibitor) at 25 mg/kg X d po increased NaCl intake in rats. Our results with captopril confirm those of Fregly (1980) and Evered and Robinson (1983) and show that both converting-enzyme inhibitors (enalapril and captopril) increase salt appetite in rats.
D H Minsker, and
W J Bagdon, and
R T Robertson, and
D L Bokelman
January 1987,
Journal of the American Veterinary Medical Association,
D H Minsker, and
W J Bagdon, and
R T Robertson, and
D L Bokelman
March 1984,
Rational drug therapy,
D H Minsker, and
W J Bagdon, and
R T Robertson, and
D L Bokelman
October 1986,
The American journal of medicine,
D H Minsker, and
W J Bagdon, and
R T Robertson, and
D L Bokelman
August 1992,
The American journal of cardiology,
D H Minsker, and
W J Bagdon, and
R T Robertson, and
D L Bokelman
December 1986,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
D H Minsker, and
W J Bagdon, and
R T Robertson, and
D L Bokelman
November 1980,
The Journal of pharmacology and experimental therapeutics,
D H Minsker, and
W J Bagdon, and
R T Robertson, and
D L Bokelman
August 1984,
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D H Minsker, and
W J Bagdon, and
R T Robertson, and
D L Bokelman
August 1990,
Agents and actions,
D H Minsker, and
W J Bagdon, and
R T Robertson, and
D L Bokelman
October 1986,
The American journal of medicine,
D H Minsker, and
W J Bagdon, and
R T Robertson, and
D L Bokelman
April 1987,
Clinical and experimental pharmacology & physiology,
