Biomaterial Database

[Circadian rhythm of the pituitary-adrenal system in rheumatoid arthritis]. 1984

R A Davletshin

Two hundred and fifty-five patients with rheumatoid arthritis (RA) were examined for the levels of free cortisol and corticotrophin as well as for their circadian rhythms. It was established that the lowering of the daily average cortisol level and corticotrophin elevation in the blood as well as the desynchronization types of circadian rhythms depended on the RA gravity and the disease clinical variety. The most pronounced decrease in the cortisol level and destabilization of pituitary-adrenal function were found in the visceral RA pattern, particularly in subjects treated with corticosteroids and in those with hormone-dependent RA. Triamcinolon gave rise to a more substantial lowering of free cortisol as compared to prednisolone. It is assumed that impairment of the synchronization role of hypothalamic formations is of importance in the genesis of neuroendocrine dysfunction in RA patients.

UI	MeSH Term	Description	Entries
D006964	Hyperpituitarism	Disease of the glandular, anterior portion of the pituitary (PITUITARY GLAND, ANTERIOR) resulting in hypersecretion of ADENOHYPOPHYSEAL HORMONES such as GROWTH HORMONE; PROLACTIN; THYROTROPIN; LUTEINIZING HORMONE; FOLLICLE STIMULATING HORMONE ; and ADRENOCORTICOTROPIC HORMONE. Hyperpituitarism usually is caused by a functional ADENOMA.	Follicle Stimulating Hormone, Inappropriate Secretion,Inappropriate FSH Secretion Syndrome,Inappropriate Follicle Stimulating Hormone Secretion,Inappropriate LH Secretion Syndrome,Inappropriate Luteinizing Hormone Secretion,Inappropriate TSH Secretion Syndrome,Inappropriate Thyroid Stimulating Hormone Secretion,Luteinizing Hormone, Inappropriate Secretion,Thyroid Stimulating Hormone, Inappropriate Secretion,Pituitary FSH Hypersecretion,Pituitary LH Hypersecretion,Pituitary TSH Hypersecretion,FSH Hypersecretion, Pituitary,Hypersecretion, Pituitary FSH,Hypersecretion, Pituitary LH,Hypersecretion, Pituitary TSH,LH Hypersecretion, Pituitary,TSH Hypersecretion, Pituitary
D010913	Pituitary-Adrenal System	The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.	Pituitary Adrenal System,Pituitary-Adrenal Systems,System, Pituitary-Adrenal,Systems, Pituitary-Adrenal
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006854	Hydrocortisone	The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.	Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol
D000309	Adrenal Insufficiency	Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.	Adrenal Gland Hypofunction,Hypoadrenalism,Adrenal Insufficiencies,Hypofunction, Adrenal Gland
D000324	Adrenocorticotropic Hormone	An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).	ACTH,Adrenocorticotropin,Corticotropin,1-39 ACTH,ACTH (1-39),Adrenocorticotrophic Hormone,Corticotrophin,Corticotrophin (1-39),Corticotropin (1-39),Hormone, Adrenocorticotrophic,Hormone, Adrenocorticotropic
D001172	Arthritis, Rheumatoid	A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	Rheumatoid Arthritis