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Serum MK-422 and plasma angiotensin converting enzyme activity were measured during the introduction of enalapril therapy in eight patients with heart failure. In a second study of 16 patients, we recorded exercise tolerance, clinical status and haemodynamics before and after 12 weeks of placebo or enalapril treatment. Increasing doses of enalapril gave step-wise increments in serum MK-422. Plasma converting enzyme activity remained low for at least 24 h after each dose of enalapril (5, 10 and 20 mg). Compared to placebo patients (n = 8), those receiving enalapril (n = 8) tended to improve their exercise performance and clinical status, and showed a fall in right heart pressures after 12 weeks of treatment.
M G Nicholls, and
H Ikram, and
E A Espiner, and
M W Webster, and
M A Fitzpatrick
April 2016,
The New England journal of medicine,
M G Nicholls, and
H Ikram, and
E A Espiner, and
M W Webster, and
M A Fitzpatrick
November 1987,
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M G Nicholls, and
H Ikram, and
E A Espiner, and
M W Webster, and
M A Fitzpatrick
February 1989,
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M G Nicholls, and
H Ikram, and
E A Espiner, and
M W Webster, and
M A Fitzpatrick
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M G Nicholls, and
H Ikram, and
E A Espiner, and
M W Webster, and
M A Fitzpatrick
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M G Nicholls, and
H Ikram, and
E A Espiner, and
M W Webster, and
M A Fitzpatrick
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M G Nicholls, and
H Ikram, and
E A Espiner, and
M W Webster, and
M A Fitzpatrick
July 1988,
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M G Nicholls, and
H Ikram, and
E A Espiner, and
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M A Fitzpatrick
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M G Nicholls, and
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M A Fitzpatrick
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M G Nicholls, and
H Ikram, and
E A Espiner, and
M W Webster, and
M A Fitzpatrick
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