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Human T-cell leukemia/lymphoma virus type I(HTLV-I) infection appears to be closely associated with the leukemogenesis of adult T-cell leukemia (ATL), although its mechanism remains unclear. Since our previous report that leukemic cells from patients with ATL expressed Tac antigen (Ag) (interleukin-2 (IL-2) receptor) on their cell surface, we have been studying IL-2 receptors on ATL leukemic cells to see whether they are different from normal IL-2 receptors and whether they play a role in the neoplastic growth of ATL cells. Peripheral blood leukemic cells from 35 patients with ATL expressed IL-2 receptors which were detected by anti-Tac monoclonal antibody when examined immediately after the separation of cells or after culture for 24 or 48 hr. The number of anti-Tac binding sites ranged from 4,300 to 11,400 in fresh cells and from 6,100 to 96,000/cell in short term cultured leukemic cells, whereas phytohemagglutinin-P(PHA-P)-stimulated normal T cells exhibited 7,000 to 35,000 anti-Tac binding sites/cell. HTLV-I-infected cell lines such as MT-1 and HUT-102 expressed a markedly enhanced number of Tac Ag molecules. Leukemic cells from 15 ATL patients showed no or very poor proliferative response to various concentrations of IL-2, although they expressed Tac Ag. Radiolabeled IL-2 binding experiments revealed that ATL leukemic cells could bind IL-2 although the number of IL-2 binding sites was much less than that of anti-Tac binding sites. IL-2 receptors on ATL cells, unlike normal activated T cells, were not modulated (down-regulated) by anti-Tac antibody.(ABSTRACT TRUNCATED AT 250 WORDS)
T Uchiyama, and
Y Wano, and
M Tsudo, and
H Umadome, and
T Hori, and
S Tamori, and
H Uchino, and
J Yodoi, and
M Maeda, and
N Kobayashi
September 1985,
Cancer research,
T Uchiyama, and
Y Wano, and
M Tsudo, and
H Umadome, and
T Hori, and
S Tamori, and
H Uchino, and
J Yodoi, and
M Maeda, and
N Kobayashi
March 1985,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Uchiyama, and
Y Wano, and
M Tsudo, and
H Umadome, and
T Hori, and
S Tamori, and
H Uchino, and
J Yodoi, and
M Maeda, and
N Kobayashi
January 1984,
Princess Takamatsu symposia,
T Uchiyama, and
Y Wano, and
M Tsudo, and
H Umadome, and
T Hori, and
S Tamori, and
H Uchino, and
J Yodoi, and
M Maeda, and
N Kobayashi
January 1987,
Methods in enzymology,
T Uchiyama, and
Y Wano, and
M Tsudo, and
H Umadome, and
T Hori, and
S Tamori, and
H Uchino, and
J Yodoi, and
M Maeda, and
N Kobayashi
May 1983,
Blood,
T Uchiyama, and
Y Wano, and
M Tsudo, and
H Umadome, and
T Hori, and
S Tamori, and
H Uchino, and
J Yodoi, and
M Maeda, and
N Kobayashi
January 1991,
Japanese journal of medicine,
T Uchiyama, and
Y Wano, and
M Tsudo, and
H Umadome, and
T Hori, and
S Tamori, and
H Uchino, and
J Yodoi, and
M Maeda, and
N Kobayashi
June 1985,
The American journal of pathology,
T Uchiyama, and
Y Wano, and
M Tsudo, and
H Umadome, and
T Hori, and
S Tamori, and
H Uchino, and
J Yodoi, and
M Maeda, and
N Kobayashi
May 1988,
American journal of clinical pathology,
T Uchiyama, and
Y Wano, and
M Tsudo, and
H Umadome, and
T Hori, and
S Tamori, and
H Uchino, and
J Yodoi, and
M Maeda, and
N Kobayashi
January 1987,
Acta haematologica,
T Uchiyama, and
Y Wano, and
M Tsudo, and
H Umadome, and
T Hori, and
S Tamori, and
H Uchino, and
J Yodoi, and
M Maeda, and
N Kobayashi
June 1985,
Science (New York, N.Y.),
