-transparent.png){kind=logo}
Extracts of rat atrial muscle lowered basal aldosterone release from rat adrenal glomerulosa cell suspensions, and partially inhibited the stimulation of aldosterone release by adrenocorticotropic hormone (ACTH) and angiotensin II. Atriopeptin I, an atrial peptide with natriuretic, diuretic and smooth muscle relaxant activities, significantly decreased basal aldosterone release at 1 pM concentrations. Also, atriopeptin I decreased the sensitivity of the glomerulosa cells to adrenocorticotropin and angiotensin II. These data suggest that peptides contained in mammalian atria affect sodium excretion not only by a direct effect on the kidney, but also indirectly through inhibition of aldosterone production.
K Atarashi, and
R Franco-Saenz, and
P J Mulrow, and
R M Snajdar, and
J P Rapp
August 1986,
Federation proceedings,
K Atarashi, and
R Franco-Saenz, and
P J Mulrow, and
R M Snajdar, and
J P Rapp
January 1984,
Nature,
K Atarashi, and
R Franco-Saenz, and
P J Mulrow, and
R M Snajdar, and
J P Rapp
June 1988,
The American journal of physiology,
K Atarashi, and
R Franco-Saenz, and
P J Mulrow, and
R M Snajdar, and
J P Rapp
January 1990,
The American journal of physiology,
K Atarashi, and
R Franco-Saenz, and
P J Mulrow, and
R M Snajdar, and
J P Rapp
December 1989,
The American journal of physiology,
K Atarashi, and
R Franco-Saenz, and
P J Mulrow, and
R M Snajdar, and
J P Rapp
December 1988,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
K Atarashi, and
R Franco-Saenz, and
P J Mulrow, and
R M Snajdar, and
J P Rapp
January 1995,
The Chinese journal of physiology,
K Atarashi, and
R Franco-Saenz, and
P J Mulrow, and
R M Snajdar, and
J P Rapp
January 1989,
Journal of endocrinological investigation,
K Atarashi, and
R Franco-Saenz, and
P J Mulrow, and
R M Snajdar, and
J P Rapp
March 1985,
Biochemical and biophysical research communications,
K Atarashi, and
R Franco-Saenz, and
P J Mulrow, and
R M Snajdar, and
J P Rapp
January 1993,
Life sciences,
