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The effects of psychotropic drugs on THC-induced long-lasting muricide were investigated in rats. Changes in open field activity (ambulation and rearing) of the rat were concurrently assessed as an index of behavioral toxicity. Imipramine-like antidepressants, atropine, and antiparkinsonism drugs exhibited a selective inhibitory activity on muricide, whereas the effects of neuroleptics, pentobarbital, diazepam, and methamphetamine were nonspecific. It is also suggested that cholinergic, catecholaminergic, and serotonergic mechanisms are involved in THC-induced muricide. This type of induced muricide appears to be a useful experimental model particularly suitable for the evaluation of antidepressants in correlation with brain amine dynamics.
M Fujiwara, and
N Ibii, and
Y Kataoka, and
S Ueki
January 1978,
Advances in the biosciences,
M Fujiwara, and
N Ibii, and
Y Kataoka, and
S Ueki
October 1972,
Physiology & behavior,
M Fujiwara, and
N Ibii, and
Y Kataoka, and
S Ueki
January 1976,
Pharmacology, biochemistry, and behavior,
M Fujiwara, and
N Ibii, and
Y Kataoka, and
S Ueki
January 1974,
Japanese journal of pharmacology,
M Fujiwara, and
N Ibii, and
Y Kataoka, and
S Ueki
January 1978,
Advances in the biosciences,
M Fujiwara, and
N Ibii, and
Y Kataoka, and
S Ueki
January 1980,
The Journal of pharmacology and experimental therapeutics,
M Fujiwara, and
N Ibii, and
Y Kataoka, and
S Ueki
January 1981,
Psychopharmacology,
M Fujiwara, and
N Ibii, and
Y Kataoka, and
S Ueki
August 1975,
Research communications in chemical pathology and pharmacology,
M Fujiwara, and
N Ibii, and
Y Kataoka, and
S Ueki
March 1976,
Clinical pharmacology and therapeutics,
M Fujiwara, and
N Ibii, and
Y Kataoka, and
S Ueki
May 1975,
Clinical pharmacology and therapeutics,
