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In 25 women with disturbances of ovulation who were treated for sterility with D-Trp-6-LHRH, a potent analog of LHRH, ovulation was achieved in nine patients, but none of these became pregnant after therapy. After using the LHRH analog combined with clomiphene citrate in 14 of these 25 women, six ovulated and only one conceived. The overall rate of ovulation after the combined therapy was better than obtained when LHRH analog alone was administered. From this study we conclude that more investigations using different regimens have to be carried out in order to establish the clinical benefit of LHRH stimulatory analogs in induction of ovulation.
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