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50 diet-treated, non-insulin-dependent diabetics were tested subjectively and objectively for chlorpropamide-alcohol flushing (CPAF) with a single challenge test. Of the 12 (24%) who reported a subjective flush, 9 (18%) also flushed when a placebo was given instead of chlorpropamide, so the true incidence of chlorpropamide-alcohol flushing was 4% (1 patient was not retested with placebo). In a control group of 21 non-diabetics, 2 showed the specific CPAF phenomenon. Temperature measurement did not improve discrimination, but it did show a faster rise in facial temperature in CPAF-positive subjects than in alcohol flushers. This study does not confirm previous higher estimates of the incidence of the CPAF phenomenon in non-insulin-dependent diabetes.
N E deSilva, and
W M Tunbridge, and
K G Alberti
November 1981,
British medical journal (Clinical research ed.),
N E deSilva, and
W M Tunbridge, and
K G Alberti
August 1980,
British medical journal,
N E deSilva, and
W M Tunbridge, and
K G Alberti
February 1981,
British medical journal (Clinical research ed.),
N E deSilva, and
W M Tunbridge, and
K G Alberti
July 1980,
British medical journal,
N E deSilva, and
W M Tunbridge, and
K G Alberti
September 1985,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
N E deSilva, and
W M Tunbridge, and
K G Alberti
December 1978,
British medical journal,
N E deSilva, and
W M Tunbridge, and
K G Alberti
February 1981,
British medical journal (Clinical research ed.),
N E deSilva, and
W M Tunbridge, and
K G Alberti
January 1984,
Diabetes care,
N E deSilva, and
W M Tunbridge, and
K G Alberti
April 1981,
Diabetologia,
N E deSilva, and
W M Tunbridge, and
K G Alberti
January 1981,
Acta medica Scandinavica. Supplementum,
