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A reverse phase high pressure liquid chromatographic method in which ion-pairing is used for the determination of combinations of pseudoephedrine hydrochloride with triprolidine hydrochloride or chlorpheniramine maleate in syrups and tablets was collaboratively studied by 8 laboratories. Collaborators were supplied with 12 samples including synthetic and commercial syrup formulations and commercial tablet composites. Mean recoveries of pseudoephedrine hydrochloride and triprolidine hydrochloride from synthetic syrup formulations were 100.5 and 99.6%, respectively. Mean recoveries of pseudoephedrine hydrochloride and chlorpheniramine maleate from synthetic syrups were 98.8 and 100.5%, respectively. Mean coefficients of variation for syrups and tablets ranged from 1.68 to 3.07% for pseudoephedrine hydrochloride, from 2.92 to 3.85% for triprolidine hydrochloride, and from 1.34 to 2.15% for chlorpheniramine maleate. The method has been adopted official first action.
W J Bachman, and
M Y Alpert, and
E Bargo, and
R E Draper, and
W H Hock, and
J Illuminati, and
M Lookabaugh, and
M Margosis, and
D W Thompson
January 1980,
Journal - Association of Official Analytical Chemists,
W J Bachman, and
M Y Alpert, and
E Bargo, and
R E Draper, and
W H Hock, and
J Illuminati, and
M Lookabaugh, and
M Margosis, and
D W Thompson
July 1983,
Journal - Association of Official Analytical Chemists,
W J Bachman, and
M Y Alpert, and
E Bargo, and
R E Draper, and
W H Hock, and
J Illuminati, and
M Lookabaugh, and
M Margosis, and
D W Thompson
May 1980,
Journal - Association of Official Analytical Chemists,
W J Bachman, and
M Y Alpert, and
E Bargo, and
R E Draper, and
W H Hock, and
J Illuminati, and
M Lookabaugh, and
M Margosis, and
D W Thompson
September 1983,
Journal - Association of Official Analytical Chemists,
W J Bachman, and
M Y Alpert, and
E Bargo, and
R E Draper, and
W H Hock, and
J Illuminati, and
M Lookabaugh, and
M Margosis, and
D W Thompson
November 1977,
Journal - Association of Official Analytical Chemists,
W J Bachman, and
M Y Alpert, and
E Bargo, and
R E Draper, and
W H Hock, and
J Illuminati, and
M Lookabaugh, and
M Margosis, and
D W Thompson
July 1978,
Journal - Association of Official Analytical Chemists,
W J Bachman, and
M Y Alpert, and
E Bargo, and
R E Draper, and
W H Hock, and
J Illuminati, and
M Lookabaugh, and
M Margosis, and
D W Thompson
March 1982,
Journal - Association of Official Analytical Chemists,
W J Bachman, and
M Y Alpert, and
E Bargo, and
R E Draper, and
W H Hock, and
J Illuminati, and
M Lookabaugh, and
M Margosis, and
D W Thompson
January 1986,
Journal - Association of Official Analytical Chemists,
W J Bachman, and
M Y Alpert, and
E Bargo, and
R E Draper, and
W H Hock, and
J Illuminati, and
M Lookabaugh, and
M Margosis, and
D W Thompson
January 1979,
Journal - Association of Official Analytical Chemists,
W J Bachman, and
M Y Alpert, and
E Bargo, and
R E Draper, and
W H Hock, and
J Illuminati, and
M Lookabaugh, and
M Margosis, and
D W Thompson
July 1977,
Journal - Association of Official Analytical Chemists,
