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To examine the effect of age on the collagen metabolism of glomerular basement membrane (GBM) and tail tendon, both structures were labeled in vivo by the injection of tracer amounts of radioactive proline. The analyses of the labeled proline and, especially, hydroxyproline revealed that synthesis and degradation are reduced in senescent rats. The calculated turnover rate for GBM-collagen is prolonged by about 40% with increased life span. The reduced catabolism is responsible for the age-related thickening of the GBM. In addition, compositional analyses of isolated GBM and tail tendon were performed. Substantial age changes were observed in the amino acid composition of both structures. The hydroxylated amino acids showed a progressive increase with age, while proline and lysine were found to decline.
T Heck, and
K Hempel, and
H W Lange, and
W Romen
January 1980,
Experimental gerontology,
T Heck, and
K Hempel, and
H W Lange, and
W Romen
January 1978,
Archives of biochemistry and biophysics,
T Heck, and
K Hempel, and
H W Lange, and
W Romen
January 1980,
Experimental gerontology,
T Heck, and
K Hempel, and
H W Lange, and
W Romen
September 1978,
The Tohoku journal of experimental medicine,
T Heck, and
K Hempel, and
H W Lange, and
W Romen
January 1987,
Nihon Jinzo Gakkai shi,
T Heck, and
K Hempel, and
H W Lange, and
W Romen
January 1982,
The International journal of biochemistry,
T Heck, and
K Hempel, and
H W Lange, and
W Romen
August 1975,
Biochemical and biophysical research communications,
T Heck, and
K Hempel, and
H W Lange, and
W Romen
April 1970,
Experimental gerontology,
T Heck, and
K Hempel, and
H W Lange, and
W Romen
January 1968,
Biochimica et biophysica acta,
T Heck, and
K Hempel, and
H W Lange, and
W Romen
February 1969,
Das Deutsche Gesundheitswesen,
