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The hypothesis that migraine is caused by a primary abnormality of platelet behaviour was investigated in a total of 77 migraine patients and control subjects. Platelets taken from patients with classical migraine during a headache-free period demonstrated significantly higher spontaneous platelet aggregation and platelet adhesion than platelets from controls. Platelet 5-hydroxytryptamine release within three days of a migraine attack was significantly less than that measured during a migraine-free interval. Platelets from migraine patients differ significantly in their behaviour from normal platelets, and these differences can explain the onset and recurrence of attacks.
E Hanington, and
R J Jones, and
J A Amess, and
B Wachowicz
December 1979,
Lancet (London, England),
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B Wachowicz
July 1987,
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E Hanington, and
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B Wachowicz
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E Hanington, and
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J A Amess, and
B Wachowicz
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E Hanington, and
R J Jones, and
J A Amess, and
B Wachowicz
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E Hanington, and
R J Jones, and
J A Amess, and
B Wachowicz
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E Hanington, and
R J Jones, and
J A Amess, and
B Wachowicz
July 1977,
Headache,
E Hanington, and
R J Jones, and
J A Amess, and
B Wachowicz
October 1978,
Lancet (London, England),
E Hanington, and
R J Jones, and
J A Amess, and
B Wachowicz
September 1978,
Lancet (London, England),
E Hanington, and
R J Jones, and
J A Amess, and
B Wachowicz
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Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove,
