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Under systemic administration tuftsin produces a marked influence on behavior and emotional reactivity in rats: enhances motor (vertical) activity, perception of pain stimulation and related aggressiveness and residual excitation. Activating effect is accompanied by an aggravation of the acquisition of passive avoidance reaction during single reinforcement. In vitro experiments revealed a direct inhibitory effect of tuftsin on the reaction rate of brain tyrosine hydroxylase activity. In vivo there was shown an increase in hypothalamic and especially striatal tyrosine hydroxylase activity. The data obtained indicate direct relationships between tuftsin central effects and the changes in brain catecholaminergic processes participating in the regulation of emotional-motivational and motor reactions.
A V Val'dman, and
M M Kozlovskaia, and
I P Ashmarin, and
M F Mineeva, and
K V Anokhin
January 1983,
Annals of the New York Academy of Sciences,
A V Val'dman, and
M M Kozlovskaia, and
I P Ashmarin, and
M F Mineeva, and
K V Anokhin
March 1979,
British journal of cancer,
A V Val'dman, and
M M Kozlovskaia, and
I P Ashmarin, and
M F Mineeva, and
K V Anokhin
January 1989,
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova,
A V Val'dman, and
M M Kozlovskaia, and
I P Ashmarin, and
M F Mineeva, and
K V Anokhin
January 1983,
Annals of the New York Academy of Sciences,
A V Val'dman, and
M M Kozlovskaia, and
I P Ashmarin, and
M F Mineeva, and
K V Anokhin
December 1975,
The Journal of pediatrics,
A V Val'dman, and
M M Kozlovskaia, and
I P Ashmarin, and
M F Mineeva, and
K V Anokhin
July 1980,
Biulleten' eksperimental'noi biologii i meditsiny,
A V Val'dman, and
M M Kozlovskaia, and
I P Ashmarin, and
M F Mineeva, and
K V Anokhin
January 1980,
Doklady Akademii nauk SSSR,
A V Val'dman, and
M M Kozlovskaia, and
I P Ashmarin, and
M F Mineeva, and
K V Anokhin
July 1989,
Immunological investigations,
A V Val'dman, and
M M Kozlovskaia, and
I P Ashmarin, and
M F Mineeva, and
K V Anokhin
January 1990,
Polish journal of pharmacology and pharmacy,
A V Val'dman, and
M M Kozlovskaia, and
I P Ashmarin, and
M F Mineeva, and
K V Anokhin
January 1979,
Advances in experimental medicine and biology,
