-transparent.png){kind=logo}
Various 2-benzodioxinylaminoethanol derivatives were synthetized and investigated for beta-adrenergic blocking activity. Most compounds demonstrated a beta-blocking activity of a competitive type when evaluated in guinea pig atrial and tracheal preparations. Three compounds were more potent than practolol and propranolol. All compounds demonstrated antihypertensive properties in spontaneously hypertensive rats. The most active compound was 1-(1,4-benzodioxin-2-yl)-2-[N4-(2-methoxyphenyl)piperazino]ethanol (11), which at 2.5 mg/kg iv lowered blood pressure by 41%.
Related Publications
L Lalloz, and
V Loppinet, and
G Coudert, and
G Guillaumet, and
B Loubinoux, and
C Labrid, and
M Beaughard, and
G Dureng, and
J C Lamar
June 1979,
Journal of medicinal chemistry,
L Lalloz, and
V Loppinet, and
G Coudert, and
G Guillaumet, and
B Loubinoux, and
C Labrid, and
M Beaughard, and
G Dureng, and
J C Lamar
November 1979,
Journal of medicinal chemistry,
L Lalloz, and
V Loppinet, and
G Coudert, and
G Guillaumet, and
B Loubinoux, and
C Labrid, and
M Beaughard, and
G Dureng, and
J C Lamar
October 1978,
Journal of medicinal chemistry,
L Lalloz, and
V Loppinet, and
G Coudert, and
G Guillaumet, and
B Loubinoux, and
C Labrid, and
M Beaughard, and
G Dureng, and
J C Lamar
September 1970,
Journal of medicinal chemistry,
L Lalloz, and
V Loppinet, and
G Coudert, and
G Guillaumet, and
B Loubinoux, and
C Labrid, and
M Beaughard, and
G Dureng, and
J C Lamar
January 1985,
Journal of cardiovascular pharmacology,
L Lalloz, and
V Loppinet, and
G Coudert, and
G Guillaumet, and
B Loubinoux, and
C Labrid, and
M Beaughard, and
G Dureng, and
J C Lamar
March 1976,
Current therapeutic research, clinical and experimental,
L Lalloz, and
V Loppinet, and
G Coudert, and
G Guillaumet, and
B Loubinoux, and
C Labrid, and
M Beaughard, and
G Dureng, and
J C Lamar
January 1982,
Journal of emergency nursing,
L Lalloz, and
V Loppinet, and
G Coudert, and
G Guillaumet, and
B Loubinoux, and
C Labrid, and
M Beaughard, and
G Dureng, and
J C Lamar
September 1982,
Midwife, health visitor & community nurse,
L Lalloz, and
V Loppinet, and
G Coudert, and
G Guillaumet, and
B Loubinoux, and
C Labrid, and
M Beaughard, and
G Dureng, and
J C Lamar
March 1967,
The New England journal of medicine,
L Lalloz, and
V Loppinet, and
G Coudert, and
G Guillaumet, and
B Loubinoux, and
C Labrid, and
M Beaughard, and
G Dureng, and
J C Lamar
January 1967,
Duodecim; laaketieteellinen aikakauskirja,
