-transparent.png){kind=logo}
A newly synthesized beta-adrenoreceptor blocking agent, DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (ZAMI 1305), administered intragastrically for 6 months induced hepatocellular carcinomas in female outbred Wistar rats in a dose-dependent fashion but was harmless to the livers of male outbred Wistar rats. Experiments with castrated animals confirmed the dependence of the carcinogenic effect of ZAMI 1305 on the hormonal status of the rat. When an isomer of ZAMI 1305, DL-1-(2-nitro-5-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (ZAMI 1327), and DL-practolol, which have pharmacologic activities similar to those of ZAMI 1305, were administered by the same experimental technique as used for ZAMI 1305, no liver tumors appeared either in male or female rats.
G Ragnotti, and
M Presta, and
L Riboni, and
T Zavanella
August 1982,
British medical journal (Clinical research ed.),
G Ragnotti, and
M Presta, and
L Riboni, and
T Zavanella
August 1976,
British journal of clinical pharmacology,
G Ragnotti, and
M Presta, and
L Riboni, and
T Zavanella
February 1982,
Clinical cardiology,
G Ragnotti, and
M Presta, and
L Riboni, and
T Zavanella
August 1986,
Rational drug therapy,
G Ragnotti, and
M Presta, and
L Riboni, and
T Zavanella
August 1979,
The Medical journal of Australia,
G Ragnotti, and
M Presta, and
L Riboni, and
T Zavanella
November 1974,
Arzneimittel-Forschung,
G Ragnotti, and
M Presta, and
L Riboni, and
T Zavanella
December 1973,
Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille,
G Ragnotti, and
M Presta, and
L Riboni, and
T Zavanella
March 1973,
Annales medicinae experimentalis et biologiae Fenniae,
G Ragnotti, and
M Presta, and
L Riboni, and
T Zavanella
September 1980,
Xenobiotica; the fate of foreign compounds in biological systems,
G Ragnotti, and
M Presta, and
L Riboni, and
T Zavanella
January 1986,
European journal of clinical pharmacology,
