-transparent.png){kind=logo}
The interactions of adrenergic and cholinergic influences on the gastric D cell were studied using an isolated perfused rat stomach in vitro. The sevenfold increase in the release of somatostatin-like immunoreactivity (SLI) in response to isoproterenol (4 . 10(-8) M) was dose-dependently inhibited by acetylcholine (10(-5) to 10(-8) M) whereas gastrin levels increased in a dose-dependent manner. Both inhibition of stimulated SLI and augmentation of gastrin release were completely abolished by atropine (10(-6) M). Isoproterenol (8 . 10(-9) M)-induced stimulation of SLI secretion was not altered by atropine. Antral exclusion completely eliminated gastrin secretion but basal and beta-adrenergic stimulated SLI release was not influenced. It is concluded that (1) cholinergic agonism reverses the stimulatory action of adrenergic agonists on the D cell, and (2) SLI from the rat stomach in vitro originates almost exclusively in the fundic region.
H Koop, and
I Behrens, and
E Bothe, and
C H McIntosh, and
R A Pederson, and
R Arnold, and
W Creutzfeldt
May 1982,
Gastroenterology,
H Koop, and
I Behrens, and
E Bothe, and
C H McIntosh, and
R A Pederson, and
R Arnold, and
W Creutzfeldt
August 1988,
Scandinavian journal of gastroenterology,
H Koop, and
I Behrens, and
E Bothe, and
C H McIntosh, and
R A Pederson, and
R Arnold, and
W Creutzfeldt
November 1986,
Gastroenterology,
H Koop, and
I Behrens, and
E Bothe, and
C H McIntosh, and
R A Pederson, and
R Arnold, and
W Creutzfeldt
March 1977,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
H Koop, and
I Behrens, and
E Bothe, and
C H McIntosh, and
R A Pederson, and
R Arnold, and
W Creutzfeldt
January 1988,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
H Koop, and
I Behrens, and
E Bothe, and
C H McIntosh, and
R A Pederson, and
R Arnold, and
W Creutzfeldt
July 1990,
Regulatory peptides,
H Koop, and
I Behrens, and
E Bothe, and
C H McIntosh, and
R A Pederson, and
R Arnold, and
W Creutzfeldt
January 1992,
Digestion,
H Koop, and
I Behrens, and
E Bothe, and
C H McIntosh, and
R A Pederson, and
R Arnold, and
W Creutzfeldt
January 1984,
Scandinavian journal of gastroenterology. Supplement,
H Koop, and
I Behrens, and
E Bothe, and
C H McIntosh, and
R A Pederson, and
R Arnold, and
W Creutzfeldt
January 1994,
Life sciences,
H Koop, and
I Behrens, and
E Bothe, and
C H McIntosh, and
R A Pederson, and
R Arnold, and
W Creutzfeldt
June 1981,
Canadian journal of physiology and pharmacology,
