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1. The present work investigates in vitro the inhibitory dose-response curves to histamine, 4-methyl-histamine and 2-pyridylethylamine in depolarized (KCl 37 mM) uterus from estrogenous sensitized rats. 2. Dose-response curves for the various agonists were obtained in the absence and presence of selective histaminergic (clemizole and cimetidine) and adrenergic (propranolol and reserpine) blocking drugs. 3. Histamine and 4-methyl-histamine, but not 2-pyridylethylamine, produced dose-dependent relaxations of the uterus. 4. Neither clemizole nor propranolol displaced the inhibitory dose-response curves for histamine. 5. After adrenergic blockade with either propranolol or reserpine, cimetidine produced a rightward displacement of the dose-response curves to histamine. 6. Theses results suggest that the inhibitory effect of histamine is mediated through activation of H2 histamine uterine receptors.
E Rubio, and
J Esplugues, and
E Marti-Bonmati, and
E Morcillo, and
F J Morales-Olivas
January 1960,
Acta pharmacologica et toxicologica,
E Rubio, and
J Esplugues, and
E Marti-Bonmati, and
E Morcillo, and
F J Morales-Olivas
January 1960,
Acta pharmacologica et toxicologica,
E Rubio, and
J Esplugues, and
E Marti-Bonmati, and
E Morcillo, and
F J Morales-Olivas
December 1973,
The Journal of pharmacology and experimental therapeutics,
E Rubio, and
J Esplugues, and
E Marti-Bonmati, and
E Morcillo, and
F J Morales-Olivas
January 1961,
Acta pharmacologica et toxicologica,
E Rubio, and
J Esplugues, and
E Marti-Bonmati, and
E Morcillo, and
F J Morales-Olivas
January 1979,
General pharmacology,
E Rubio, and
J Esplugues, and
E Marti-Bonmati, and
E Morcillo, and
F J Morales-Olivas
May 1974,
Acta pharmacologica et toxicologica,
E Rubio, and
J Esplugues, and
E Marti-Bonmati, and
E Morcillo, and
F J Morales-Olivas
January 1994,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
E Rubio, and
J Esplugues, and
E Marti-Bonmati, and
E Morcillo, and
F J Morales-Olivas
September 1973,
The American journal of physiology,
E Rubio, and
J Esplugues, and
E Marti-Bonmati, and
E Morcillo, and
F J Morales-Olivas
May 1979,
British journal of pharmacology,
E Rubio, and
J Esplugues, and
E Marti-Bonmati, and
E Morcillo, and
F J Morales-Olivas
March 1977,
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