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Lorazepam was compared with diazepam for the treatment of status epilepticus in a double-blind, randomized trial. Seventy-eight patients with 81 episodes were enrolled. Patients received one or two doses of either 4 mg of lorazepam or 10 mg of diazepam intravenously. Seizures were controlled in 89% of the episodes treated with lorazepam and in 76% treated with diazepam. The times for onset of action of the medications did not differ significantly. Adverse effects occurred in 13% of the lorazepam-treated patients and in 12% of the diazepam-treated patients. Respiratory depression and arrest, the most frequent adverse effects, were treated symptomatically; no adverse sequelae were noted.
I E Leppik, and
A T Derivan, and
R W Homan, and
J Walker, and
R E Ramsay, and
B Patrick
May 2016,
CJEM,
I E Leppik, and
A T Derivan, and
R W Homan, and
J Walker, and
R E Ramsay, and
B Patrick
January 1992,
The Journal of emergency medicine,
I E Leppik, and
A T Derivan, and
R W Homan, and
J Walker, and
R E Ramsay, and
B Patrick
January 1988,
Pediatric neurology,
I E Leppik, and
A T Derivan, and
R W Homan, and
J Walker, and
R E Ramsay, and
B Patrick
April 1983,
British journal of anaesthesia,
I E Leppik, and
A T Derivan, and
R W Homan, and
J Walker, and
R E Ramsay, and
B Patrick
July 2016,
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia,
I E Leppik, and
A T Derivan, and
R W Homan, and
J Walker, and
R E Ramsay, and
B Patrick
June 2006,
Emergency medicine journal : EMJ,
I E Leppik, and
A T Derivan, and
R W Homan, and
J Walker, and
R E Ramsay, and
B Patrick
January 1983,
Neuropsychobiology,
I E Leppik, and
A T Derivan, and
R W Homan, and
J Walker, and
R E Ramsay, and
B Patrick
August 1995,
Developmental medicine and child neurology,
I E Leppik, and
A T Derivan, and
R W Homan, and
J Walker, and
R E Ramsay, and
B Patrick
April 2002,
QJM : monthly journal of the Association of Physicians,
I E Leppik, and
A T Derivan, and
R W Homan, and
J Walker, and
R E Ramsay, and
B Patrick
January 2014,
JAMA,
