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Platelet alpha 2-adrenoceptor binding characteristics were investigated in 28 healthy women during the peripartum period. The number of platelet alpha 2-adrenoceptors fell after childbirth, corresponding to a fall in the circulating levels of oestrogen and progesterone. Two-thirds of the women had an episode of maternity blues. At 7-10 days post partum the platelet alpha 2-adrenoceptor capacity in these subjects was significantly higher than in those women who did not show signs of maternity blues and significantly higher than a control group of normally menstruating women. We conclude that platelet alpha 2-adrenoceptors may be affected by the circulating levels of endogenous oestrogen and progesterone and that a delayed or diminished fall in platelet alpha 2-adrenoceptor capacity after childbirth may be associated with the development of maternity blues.
A Metz, and
K Stump, and
P J Cowen, and
J M Elliott, and
M G Gelder, and
D G Grahame-Smith
March 1988,
The British journal of psychiatry : the journal of mental science,
A Metz, and
K Stump, and
P J Cowen, and
J M Elliott, and
M G Gelder, and
D G Grahame-Smith
September 1987,
The British journal of psychiatry : the journal of mental science,
A Metz, and
K Stump, and
P J Cowen, and
J M Elliott, and
M G Gelder, and
D G Grahame-Smith
September 1988,
The Australian and New Zealand journal of psychiatry,
A Metz, and
K Stump, and
P J Cowen, and
J M Elliott, and
M G Gelder, and
D G Grahame-Smith
October 1988,
Headache,
A Metz, and
K Stump, and
P J Cowen, and
J M Elliott, and
M G Gelder, and
D G Grahame-Smith
July 1987,
British journal of clinical pharmacology,
A Metz, and
K Stump, and
P J Cowen, and
J M Elliott, and
M G Gelder, and
D G Grahame-Smith
July 1983,
Clinical endocrinology,
A Metz, and
K Stump, and
P J Cowen, and
J M Elliott, and
M G Gelder, and
D G Grahame-Smith
July 2002,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
A Metz, and
K Stump, and
P J Cowen, and
J M Elliott, and
M G Gelder, and
D G Grahame-Smith
April 2009,
La Revue du praticien,
A Metz, and
K Stump, and
P J Cowen, and
J M Elliott, and
M G Gelder, and
D G Grahame-Smith
January 2004,
Soins. Psychiatrie,
A Metz, and
K Stump, and
P J Cowen, and
J M Elliott, and
M G Gelder, and
D G Grahame-Smith
January 1989,
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica,
