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In five conscious dogs with chronic gastric fistulas we studied the effect of somatostatin solutions on pentagastrin-stimulated acid secretion. Somatostatin was dissolved in 0.154 M NaCl alone or in the same amount of saline to which dog albumin had been added to give a 0.5% solution. Somatostatin produced a dose-dependent inhibition of pentagastrin-stimulated gastric secretion. However, the inhibition was significantly less when somatostatin was dissolved in saline as compared to saline plus albumin. This study suggests that albumin should be added to somatostatin solutions to preserve biological activity, and it confirms previous reports indicating that, without albumin, basic peptides have a tendency to stick to infusion systems.
C Beglinger, and
C Knezevic, and
L Jeker, and
U Grötzinger, and
K Gyr
January 1986,
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C Beglinger, and
C Knezevic, and
L Jeker, and
U Grötzinger, and
K Gyr
August 1983,
The American journal of physiology,
C Beglinger, and
C Knezevic, and
L Jeker, and
U Grötzinger, and
K Gyr
September 1984,
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C Beglinger, and
C Knezevic, and
L Jeker, and
U Grötzinger, and
K Gyr
January 1981,
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C Beglinger, and
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K Gyr
January 1992,
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C Beglinger, and
C Knezevic, and
L Jeker, and
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K Gyr
May 1989,
Scandinavian journal of gastroenterology,
C Beglinger, and
C Knezevic, and
L Jeker, and
U Grötzinger, and
K Gyr
August 1986,
Scandinavian journal of gastroenterology,
C Beglinger, and
C Knezevic, and
L Jeker, and
U Grötzinger, and
K Gyr
October 1985,
Scandinavian journal of gastroenterology,
C Beglinger, and
C Knezevic, and
L Jeker, and
U Grötzinger, and
K Gyr
January 1982,
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C Beglinger, and
C Knezevic, and
L Jeker, and
U Grötzinger, and
K Gyr
January 1977,
Scandinavian journal of gastroenterology,
