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One hundred fifty patients with toxic and scintigraphically diffuse goiter were HLA typed (A, B, C, DR). One group consisted of 101 patients with concomitant Graves' ophthalmopathy and/or TSH-binding inhibiting antibodies (TBIAb). Forty nine patients had neither ophthalmopathy nor TBIAb. The former group showed a higher prevalence of HLA-B8 and DR3 compared to a normal control group. The latter group showed a higher frequency of HLA-DR5, whereas the HLA-B8 and DR3 antigens were slightly below normal prevalence. These data indicate an immunogenetic heterogeneity in patients with toxic diffuse goiter. A group of 47 hyperthyroid patients with single autonomous thyroid adenoma had no increased prevalence of any HLA-antigens. Patients with long term remission did not show an altered prevalence of any of the HLA antigens compared to controls. In contrast, patients with Graves' ophthalmopathy and/or TBIAb activity who relapsed had a significantly higher prevalence of HLA-B8 DR3, whereas patients without TBIAb and eye signs who relapsed had a significantly higher prevalence of HLA-DR5 than the control group.
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G Schernthaner, and
W R Mayr, and
P Kotulla, and
U Bogner, and
R Finke, and
H Meinhold, and
K Koppenhagen, and
K W Wenzel
March 1970,
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H Schleusener, and
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U Bogner, and
R Finke, and
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K Koppenhagen, and
K W Wenzel
January 1991,
Problemy endokrinologii,
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G Schernthaner, and
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K W Wenzel
October 1990,
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H Schleusener, and
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K Koppenhagen, and
K W Wenzel
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H Schleusener, and
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K Koppenhagen, and
K W Wenzel
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R Finke, and
H Meinhold, and
K Koppenhagen, and
K W Wenzel
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H Schleusener, and
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K Koppenhagen, and
K W Wenzel
January 1994,
Terapevticheskii arkhiv,
H Schleusener, and
G Schernthaner, and
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H Meinhold, and
K Koppenhagen, and
K W Wenzel
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January 1993,
Terapevticheskii arkhiv,
