Biomaterial Database

Hepatic microsomal O-de-ethylases in cod (Gadus morhua): their induction by Aroclor 1254 but not by Aroclor 1016. 1983

P D Hansen, and R F Addison, and D E Willis

1. The characteristics of hepatic ethoxycoumarin and ethoxyresorufin O-de-ethylases in juvenile cod (Gadus morhua) from the North Sea are described. 2. Feeding Aroclor 1254 to juvenile cod to produce liver concentrations of approx 900 microgram X g-1 (wet wt) induced ethoxycoumarin O-de-ethylase approx 30-fold, but had no effect on ethoxyresorufin O-deethylase activity. 3. Feeding Aroclor 1016 to juvenile cod to produce liver concentrations of approx 300 micrograms X g-1 (wet wt.) did not induce ethoxycoumarin O-de-ethylase activity.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008862	Microsomes, Liver	Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.	Liver Microsomes,Liver Microsome,Microsome, Liver
D010088	Oxidoreductases	The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)	Dehydrogenases,Oxidases,Oxidoreductase,Reductases,Dehydrogenase,Oxidase,Reductase
D010105	Oxygenases	Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.	Oxygenase
D011078	Polychlorinated Biphenyls	Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.	PCBs,Polychlorinated Biphenyl,Polychlorobiphenyl Compounds,Biphenyl, Polychlorinated,Biphenyls, Polychlorinated,Compounds, Polychlorobiphenyl
D005399	Fishes	A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001140	Aroclors	Industrial chemicals which have become widespread environmental pollutants. Each aroclor is a mixture of chlorinated biphenyls (1200 series) or chlorinated terphenyls (5400 series) or a combination of both (4400 series).	Aroclor
D013329	Structure-Activity Relationship	The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.	Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D015660	7-Alkoxycoumarin O-Dealkylase	A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The enzyme is cytochrome P-450- dependent.	7-Ethoxycoumarin O-Dealkylase,7-Ethoxycoumarin O-Deethylase,7-Ethoxycoumarin Dealkylase,7-Ethoxycoumarin Hydroxylase,7-Ethoxycoumarin Monooxygenase,7-Ethoxycoumarin O-De-Ethylase,7-Propoxycoumarin O-Depropylase,Cytochrome P-450-Dependent O-Dealkylase,Ethoxycoumarin Deethylase,Ethoxycoumarin O-Deethylase,7 Alkoxycoumarin O Dealkylase,7 Ethoxycoumarin Dealkylase,7 Ethoxycoumarin Hydroxylase,7 Ethoxycoumarin Monooxygenase,7 Ethoxycoumarin O De Ethylase,7 Ethoxycoumarin O Dealkylase,7 Ethoxycoumarin O Deethylase,7 Propoxycoumarin O Depropylase,Cytochrome P 450 Dependent O Dealkylase,Dealkylase, 7-Ethoxycoumarin,Deethylase, Ethoxycoumarin,Ethoxycoumarin O Deethylase,Hydroxylase, 7-Ethoxycoumarin,Monooxygenase, 7-Ethoxycoumarin,O-Deethylase, 7-Ethoxycoumarin,O-Depropylase, 7-Propoxycoumarin,P-450-Dependent O-Dealkylase, Cytochrome