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The heart rate of the anaesthetized rabbit was slowed by electrical stimulation of the hypothalamus with 7-9 sec trains of 250-330 microA pulses, duration 1 msec, frequency 60 Hz. This vagally-mediated cardio-decelerator response was attenuated in a dose-dependent manner after intravenous administration of phenoxybenzamine (0.01-5 mg/kg), phentolamine (0.01-3 mg/kg) or yohimbine (0.1-5 mg/kg). The attenuation of the cardio-decelerator response was not due to any vagolytic action of these drugs nor to block of the baroreceptor reflex, but appeared to be due to a central block of pathways descending from the hypothalamus. Propranolol, haloperidol, pimozide and spiperone did not show this central blocking action except in very large doses when there was evidence of some alpha-adrenoceptor blockade.
M H Evans, and
M R Sutton, and
N M Williamson
November 1987,
European journal of pharmacology,
M H Evans, and
M R Sutton, and
N M Williamson
January 1979,
Acta physiologica Scandinavica,
M H Evans, and
M R Sutton, and
N M Williamson
January 1975,
Neuroendocrinology,
M H Evans, and
M R Sutton, and
N M Williamson
October 2005,
Autonomic neuroscience : basic & clinical,
M H Evans, and
M R Sutton, and
N M Williamson
March 1983,
The Journal of pharmacology and experimental therapeutics,
M H Evans, and
M R Sutton, and
N M Williamson
September 1973,
British journal of pharmacology,
M H Evans, and
M R Sutton, and
N M Williamson
January 1979,
West African journal of pharmacology and drug research,
M H Evans, and
M R Sutton, and
N M Williamson
January 1972,
Naunyn-Schmiedeberg's archives of pharmacology,
M H Evans, and
M R Sutton, and
N M Williamson
September 1985,
Acta pharmacologica et toxicologica,
M H Evans, and
M R Sutton, and
N M Williamson
March 1985,
British journal of pharmacology,
