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In vitro studies were performed using the rat phrenic nerve-hemidiaphragm preparation to investigate possible interactions between diisopropyl phenol and its solvent, cremophor, with three neuromuscular blocking drugs. Cumulative concentration curves were constructed for the neuromuscular blockers and linear regression analyses performed. Differences in the calculated effective concentration to produce a 50% decrease in twitch height (EC50) and slope showed that diisopropyl phenol potentiated the action of suxamethonium, vecuronium (Org NC 45) and pancuronium. Cremophor potentiated the action of suxamethonium but antagonized the action of the non-depolarizing neuromuscular blockers. The possible mechanisms of action are discussed.
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L H Booij, and
F van der Pol, and
E N Robertson, and
J F Crul
December 1985,
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R J Fragen, and
L H Booij, and
F van der Pol, and
E N Robertson, and
J F Crul
July 1986,
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March 1989,
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R J Fragen, and
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F van der Pol, and
E N Robertson, and
J F Crul
October 1984,
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R J Fragen, and
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R J Fragen, and
L H Booij, and
F van der Pol, and
E N Robertson, and
J F Crul
May 1987,
British journal of anaesthesia,
R J Fragen, and
L H Booij, and
F van der Pol, and
E N Robertson, and
J F Crul
August 1985,
British journal of anaesthesia,
R J Fragen, and
L H Booij, and
F van der Pol, and
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J F Crul
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R J Fragen, and
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J F Crul
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R J Fragen, and
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J F Crul
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