-transparent.png){kind=logo}
In conscious rabbits, the intravenous administration of pindolol (1.25 mg/kg), propranolol (1 mg/kg) and alprenolol (2 mg/kg) induced a highly significant decrease of mean arterial blood pressure and significant bradycardia. In the same model, the intravenous administration of saline, indomethacin, and clidanac did not affect the mean arterial blood pressure and heart rate. Pretreatment with indomethacin and clidanac reduced the effect of these beta-blockers on the mean arterial blood pressure and had no effect on the heart rate. Treating of the guinea pig heart homogenate with 1 microM indomethacin or clidanac decreased the number of beta-adrenoceptors without changing their affinity. These results suggest that indomethacin and clidanac interfere with beta-adrenoceptor-mediated effects.
H Imai, and
M Niwa, and
M Nozaki, and
K Tsurumi, and
H Fujimura
August 1976,
Australian and New Zealand journal of medicine,
H Imai, and
M Niwa, and
M Nozaki, and
K Tsurumi, and
H Fujimura
February 2014,
The Cochrane database of systematic reviews,
H Imai, and
M Niwa, and
M Nozaki, and
K Tsurumi, and
H Fujimura
March 2016,
The Cochrane database of systematic reviews,
H Imai, and
M Niwa, and
M Nozaki, and
K Tsurumi, and
H Fujimura
September 2000,
Hypertension (Dallas, Tex. : 1979),
H Imai, and
M Niwa, and
M Nozaki, and
K Tsurumi, and
H Fujimura
August 2015,
The Cochrane database of systematic reviews,
H Imai, and
M Niwa, and
M Nozaki, and
K Tsurumi, and
H Fujimura
October 1983,
Zeitschrift fur Kardiologie,
H Imai, and
M Niwa, and
M Nozaki, and
K Tsurumi, and
H Fujimura
September 2020,
The Cochrane database of systematic reviews,
H Imai, and
M Niwa, and
M Nozaki, and
K Tsurumi, and
H Fujimura
December 2011,
Harvard heart letter : from Harvard Medical School,
H Imai, and
M Niwa, and
M Nozaki, and
K Tsurumi, and
H Fujimura
September 2005,
Cleveland Clinic journal of medicine,
H Imai, and
M Niwa, and
M Nozaki, and
K Tsurumi, and
H Fujimura
January 2010,
The Cochrane database of systematic reviews,
