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The effects of the anabolic steroid trenbolone acetate (TBA) on adrenal function and hepatic enzyme activity have been studied in growing female rats. Treatment with TBA resulted in a decrease in the peak of plasma corticosterone concentration which occurred during the afternoon. The enzymes tyrosine aminotransferase (TAT) and phosphoenolpyruvate carboxykinase were measured in the livers of treated and control rats. Activities of both enzymes were maximal at 22.00 h, but that of TAT was reduced in TBA-treated rats. After injection of ACTH, TBA-treated rats showed a smaller increase in plasma corticosterone than did controls. Treatment with TBA did not affect the induction of TAT activity after corticosterone treatment. All TBA-treated rats grew significantly faster than controls and the possible relevance of this reduced adrenal function to the increased growth rate is discussed.
K M Thomas, and
R G Rodway
September 1983,
The British journal of nutrition,
K M Thomas, and
R G Rodway
July 1987,
The Journal of nutrition,
K M Thomas, and
R G Rodway
August 1969,
The American journal of physiology,
K M Thomas, and
R G Rodway
March 1963,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K M Thomas, and
R G Rodway
June 1963,
Endocrinology,
K M Thomas, and
R G Rodway
January 2004,
Journal of medicinal food,
K M Thomas, and
R G Rodway
September 1979,
The Proceedings of the Nutrition Society,
K M Thomas, and
R G Rodway
January 2004,
Drug metabolism and drug interactions,
K M Thomas, and
R G Rodway
March 2001,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
K M Thomas, and
R G Rodway
January 1976,
Endocrinology,
