-transparent.png){kind=logo}
A teratogenicity study was carried out in Crj: CD (SD) rats orally administered ranitidine hydrochloride, a histamine H2-receptor antagonist, at dose levels of 50, 200 and 800 mg/kg/day as base weight for a period of 11 days from day 7 to day 17 of gestation. Two-thirds of the pregnant females in each group were sacrificed on day 20 of gestation and their fetuses were examined. The remaining dams were allowed to litter naturally, and the postnatal development of the offspring was observed. The incidences of external, internal, and skeletal anomalies were not significantly increased in the fetuses of any treated group. Ranitidine treatment caused no effects on parturition, lactation, postnatal growth and reproductive ability of the male and female offspring.
N Higashida, and
S Kamada, and
M Sakanoue, and
M Takeuchi, and
K Simpo, and
T Tanabe
January 1983,
The Journal of toxicological sciences,
N Higashida, and
S Kamada, and
M Sakanoue, and
M Takeuchi, and
K Simpo, and
T Tanabe
January 1983,
The Journal of toxicological sciences,
N Higashida, and
S Kamada, and
M Sakanoue, and
M Takeuchi, and
K Simpo, and
T Tanabe
June 1984,
The Journal of toxicological sciences,
N Higashida, and
S Kamada, and
M Sakanoue, and
M Takeuchi, and
K Simpo, and
T Tanabe
December 1983,
Drug intelligence & clinical pharmacy,
N Higashida, and
S Kamada, and
M Sakanoue, and
M Takeuchi, and
K Simpo, and
T Tanabe
August 1985,
The Journal of toxicological sciences,
N Higashida, and
S Kamada, and
M Sakanoue, and
M Takeuchi, and
K Simpo, and
T Tanabe
December 1997,
The Journal of toxicological sciences,
N Higashida, and
S Kamada, and
M Sakanoue, and
M Takeuchi, and
K Simpo, and
T Tanabe
April 1985,
Journal of the National Medical Association,
N Higashida, and
S Kamada, and
M Sakanoue, and
M Takeuchi, and
K Simpo, and
T Tanabe
January 1995,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
N Higashida, and
S Kamada, and
M Sakanoue, and
M Takeuchi, and
K Simpo, and
T Tanabe
August 1977,
Archivos de farmacologia y toxicologia,
N Higashida, and
S Kamada, and
M Sakanoue, and
M Takeuchi, and
K Simpo, and
T Tanabe
January 1993,
Reproductive toxicology (Elmsford, N.Y.),
