Neuropeptide Y distribution in the rat brain. 1983

Y S Allen, and T E Adrian, and J M Allen, and K Tatemoto, and T J Crow, and S R Bloom, and J M Polak

A massive neuronal system was detected by immunocytochemistry and radioimmunoassay with antibodies to neuropeptide Y, the recently isolated peptide of the pancreatic polypeptide family. Immunoreactive cell bodies and fibers were most prevalent in cortical, limbic, and hypothalamic regions. Neuropeptide Y was extracted in concentrations higher than those of any other peptide hitherto discovered in the mammalian brain. Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for immunostaining of pancreatic polypeptide-like immunoreactivity in the mammalian brain.

UI MeSH Term Description Entries
D009419 Nerve Tissue Proteins Proteins, Nerve Tissue,Tissue Proteins, Nerve
D009478 Neuropeptide Y A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones. Neuropeptide Y-Like Immunoreactive Peptide,Neuropeptide Tyrosine,Neuropeptide Y Like Immunoreactive Peptide,Tyrosine, Neuropeptide
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014018 Tissue Distribution Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D018377 Neurotransmitter Agents Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. Nerve Transmitter Substance,Neurohormone,Neurohumor,Neurotransmitter Agent,Nerve Transmitter Substances,Neurohormones,Neurohumors,Neuromodulator,Neuromodulators,Neuroregulator,Neuroregulators,Neurotransmitter,Neurotransmitters,Substances, Nerve Transmitter,Transmitter Substances, Nerve,Substance, Nerve Transmitter,Transmitter Substance, Nerve

Related Publications

Y S Allen, and T E Adrian, and J M Allen, and K Tatemoto, and T J Crow, and S R Bloom, and J M Polak
December 1984, European journal of biochemistry,
Y S Allen, and T E Adrian, and J M Allen, and K Tatemoto, and T J Crow, and S R Bloom, and J M Polak
January 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Y S Allen, and T E Adrian, and J M Allen, and K Tatemoto, and T J Crow, and S R Bloom, and J M Polak
January 1987, Neuroscience letters,
Y S Allen, and T E Adrian, and J M Allen, and K Tatemoto, and T J Crow, and S R Bloom, and J M Polak
March 1987, Neuroscience letters,
Y S Allen, and T E Adrian, and J M Allen, and K Tatemoto, and T J Crow, and S R Bloom, and J M Polak
January 1986, Peptides,
Y S Allen, and T E Adrian, and J M Allen, and K Tatemoto, and T J Crow, and S R Bloom, and J M Polak
July 1986, Brain research,
Y S Allen, and T E Adrian, and J M Allen, and K Tatemoto, and T J Crow, and S R Bloom, and J M Polak
March 2001, Molecular and cellular endocrinology,
Y S Allen, and T E Adrian, and J M Allen, and K Tatemoto, and T J Crow, and S R Bloom, and J M Polak
April 1987, Proceedings of the National Science Council, Republic of China. Part B, Life sciences,
Y S Allen, and T E Adrian, and J M Allen, and K Tatemoto, and T J Crow, and S R Bloom, and J M Polak
April 2010, Neuropeptides,
Y S Allen, and T E Adrian, and J M Allen, and K Tatemoto, and T J Crow, and S R Bloom, and J M Polak
January 2005, Pharmacological reports : PR,
Copied contents to your clipboard!