Biomaterial Database

Glutamic acid and glutamic acid diethylester in tinnitus treatment. 1983

K Ehrenberger, and R Brix

Numerous recent findings indicate that in mammals glutamic acid (Glu) functions as the primary and secondary afferent cochlear transmitter, or at least as an agonist of the main transmitter. Glutamic acid diethylester (GDEE) is one of the known antagonists of Glu. A long term suppression of certain forms of tinnitus was observed dependent on the sequence, amount and perfusion rate upon i.v. application of Glu and GDEE. Consecutive controls with tinnitus detecting as well as blind studies helped to objectify the subjective sensations of the patients.

UI	MeSH Term	Description	Entries
D005971	Glutamates	Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.	Glutamic Acid Derivatives,Glutamic Acids,Glutaminic Acids
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014012	Tinnitus	A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.	Pulsatile Tinnitus,Ringing-Buzzing-Tinnitus,Spontaneous Oto-Acoustic Emission Tinnitus,Tensor Palatini Induced Tinnitus,Tensor Tympani Induced Tinnitus,Tinnitus of Vascular Origin,Tinnitus, Clicking,Tinnitus, Leudet,Tinnitus, Leudet's,Tinnitus, Noise Induced,Tinnitus, Objective,Tinnitus, Spontaneous Oto-Acoustic Emission,Tinnitus, Subjective,Tinnitus, Tensor Palatini Induced,Tinnitus, Tensor Tympani Induced,Vascular Origin Tinnitus,Clicking Tinnitus,Induced Tinnitus, Noise,Leudet Tinnitus,Leudet's Tinnitus,Noise Induced Tinnitus,Objective Tinnitus,Ringing Buzzing Tinnitus,Spontaneous Oto Acoustic Emission Tinnitus,Subjective Tinnitus,Tinnitus, Leudets,Tinnitus, Pulsatile,Tinnitus, Spontaneous Oto Acoustic Emission,Tinnitus, Vascular Origin
D018698	Glutamic Acid	A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.	Aluminum L-Glutamate,Glutamate,Potassium Glutamate,D-Glutamate,Glutamic Acid, (D)-Isomer,L-Glutamate,L-Glutamic Acid,Aluminum L Glutamate,D Glutamate,Glutamate, Potassium,L Glutamate,L Glutamic Acid,L-Glutamate, Aluminum