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In the present study the dose-related effects of linear and cyclic somatostatin were compared on the self-stimulation rate of rats. Twenty micrograms of linear somatostatin administered intracerebroventricularly (icv.) markedly decreased the self-stimulation rate, while 5 micrograms and 10 micrograms was ineffective. Cyclic somatostatin in a dose of 1 microgram caused a transitory but not significant increase in the self-stimulation rate, which later returned to the control level. Five micrograms and 10 micrograms of the peptide decreased the self-stimulation rate. These results indicate that the cyclic somatostatin is more effective in inhibiting the self-stimulation rate than the linear one.
L Vécsei, and
H Schwarzberg, and
G Telegdy
January 1983,
Acta physiologica Hungarica,
L Vécsei, and
H Schwarzberg, and
G Telegdy
December 1984,
Pharmacology, biochemistry, and behavior,
L Vécsei, and
H Schwarzberg, and
G Telegdy
April 1988,
European journal of pharmacology,
L Vécsei, and
H Schwarzberg, and
G Telegdy
January 1985,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
L Vécsei, and
H Schwarzberg, and
G Telegdy
December 2007,
Cancer biotherapy & radiopharmaceuticals,
L Vécsei, and
H Schwarzberg, and
G Telegdy
January 1982,
Mineral and electrolyte metabolism,
L Vécsei, and
H Schwarzberg, and
G Telegdy
July 2012,
Biomacromolecules,
L Vécsei, and
H Schwarzberg, and
G Telegdy
March 2015,
ACS combinatorial science,
L Vécsei, and
H Schwarzberg, and
G Telegdy
September 1978,
Metabolism: clinical and experimental,
L Vécsei, and
H Schwarzberg, and
G Telegdy
January 1988,
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova,
