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Rabbit ear arteries were isolated and perfused with Krebs-bicarbonate solution. Brief periods of supramaximal nerve stimulation caused reproducible constriction of the arteries, which was inhibited by dopamine at concentrations ranging from 3.3 X 10(-9) to 3.3 X 10(-7) M. The inhibitory effect of dopamine was antagonized by sulpiride and by verapamil. The dose-response curve to dopamine was shifted to the right by both sulpiride and verapamil, indicative of competitive inhibition. The dopamine antagonist activity of verapamil does not appear to be a consequence of its Ca++ channel inhibitory activity because other calcium antagonists (e.g., nitrendipine and diltiazem) had no similar action.
C E Johnson, and
O S Steinsland, and
A Scriabine
January 1988,
Journal of cardiovascular pharmacology,
C E Johnson, and
O S Steinsland, and
A Scriabine
December 1986,
Life sciences,
C E Johnson, and
O S Steinsland, and
A Scriabine
January 1983,
Mineral and electrolyte metabolism,
C E Johnson, and
O S Steinsland, and
A Scriabine
August 1952,
Canadian journal of medical sciences,
C E Johnson, and
O S Steinsland, and
A Scriabine
April 1988,
Japanese journal of pharmacology,
C E Johnson, and
O S Steinsland, and
A Scriabine
January 1994,
Journal of cardiovascular pharmacology,
C E Johnson, and
O S Steinsland, and
A Scriabine
August 1978,
The Australian journal of experimental biology and medical science,
C E Johnson, and
O S Steinsland, and
A Scriabine
February 1987,
Japanese circulation journal,
C E Johnson, and
O S Steinsland, and
A Scriabine
January 1982,
Blood vessels,
C E Johnson, and
O S Steinsland, and
A Scriabine
January 1981,
Experientia,
