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Non-cytotoxic antibodies to paternal B lymphocytes were detected in sera from 11 of 11 multiparous women and from 11 of 16 normal primigravidae during the first trimester of pregnancy. These antibodies were not, however, detected in sera from 9 of 10 women of comparable gestation at the time of spontaneous abortion. By means of a rosette inhibition assay, the difference in antibody activity between the primigravidae (mean 37.9 +/- 19%, median 36.5%) and the women subject to spontaneous abortion (mean 7.3 +/- 11.6%, median 0%) was statistically significant. This antibody activity was not directed to the known HLA specificities (HLA--A, B, C, or DR), but linkage to the HLA gene complex was suggested by family studies. These results provide evidence for an HLA-linked antigen system not defined by conventional tissue-typing techniques. Fetomaternal disparity at this antigenic site may be important for successful pregnancy.
D A Power, and
G R Catto, and
R J Mason, and
A M MacLeod, and
G M Stewart, and
K N Stewart, and
W G Shewan
December 1984,
American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction,
D A Power, and
G R Catto, and
R J Mason, and
A M MacLeod, and
G M Stewart, and
K N Stewart, and
W G Shewan
November 1983,
The Journal of investigative dermatology,
D A Power, and
G R Catto, and
R J Mason, and
A M MacLeod, and
G M Stewart, and
K N Stewart, and
W G Shewan
September 1973,
Lijecnicki vjesnik,
D A Power, and
G R Catto, and
R J Mason, and
A M MacLeod, and
G M Stewart, and
K N Stewart, and
W G Shewan
January 1985,
Genetic epidemiology,
D A Power, and
G R Catto, and
R J Mason, and
A M MacLeod, and
G M Stewart, and
K N Stewart, and
W G Shewan
January 1984,
Clinical and investigative medicine. Medecine clinique et experimentale,
D A Power, and
G R Catto, and
R J Mason, and
A M MacLeod, and
G M Stewart, and
K N Stewart, and
W G Shewan
March 1987,
Journal of immunology (Baltimore, Md. : 1950),
D A Power, and
G R Catto, and
R J Mason, and
A M MacLeod, and
G M Stewart, and
K N Stewart, and
W G Shewan
February 1987,
Transplantation proceedings,
D A Power, and
G R Catto, and
R J Mason, and
A M MacLeod, and
G M Stewart, and
K N Stewart, and
W G Shewan
February 1994,
Politics and the life sciences : the journal of the Association for Politics and the Life Sciences,
D A Power, and
G R Catto, and
R J Mason, and
A M MacLeod, and
G M Stewart, and
K N Stewart, and
W G Shewan
February 1984,
Immunology today,
D A Power, and
G R Catto, and
R J Mason, and
A M MacLeod, and
G M Stewart, and
K N Stewart, and
W G Shewan
December 2022,
Transplant immunology,
