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Beta-adrenergic receptors were characterized in a particulate fraction of human auricles obtained from patients operated upon for coronary insufficiency or valvular disease. [125I] Hydroxybenzylpindolol binding was evaluated in terms of kinetics; KD and Bmax values; and inhibition of binding in the presence of 10 microM GTP and of increasing concentrations of four nonselective agonists giving a Hill coefficient of 1 (isoproterenol, salbutamol, fenoterol, and epinephrine), of two nonselective antagonists giving a Hill coefficient of 1 (pindolol and propranolol), and of a series of selective drugs giving a Hill coefficient of 0.60-0.72 that included three beta 1-selective antagonists (practolol, metoprolol, and atenolol) and two beta 2- selective agonists (procaterol and zinterol). KD values for all drugs were compatible with the coexistence in membranes from human auricles of beta 1- and beta 2-adrenergic receptors, the relative proportions of receptors of each subclass being approximately the same.
P Robberecht, and
M Delhaye, and
G Taton, and
P De Neef, and
M Waelbroeck, and
J M De Smet, and
J L Leclerc, and
P Chatelain, and
J Christophe
December 1987,
The Biochemical journal,
P Robberecht, and
M Delhaye, and
G Taton, and
P De Neef, and
M Waelbroeck, and
J M De Smet, and
J L Leclerc, and
P Chatelain, and
J Christophe
August 1983,
Life sciences,
P Robberecht, and
M Delhaye, and
G Taton, and
P De Neef, and
M Waelbroeck, and
J M De Smet, and
J L Leclerc, and
P Chatelain, and
J Christophe
February 1993,
Circulation,
P Robberecht, and
M Delhaye, and
G Taton, and
P De Neef, and
M Waelbroeck, and
J M De Smet, and
J L Leclerc, and
P Chatelain, and
J Christophe
April 1999,
Cardiovascular drugs and therapy,
P Robberecht, and
M Delhaye, and
G Taton, and
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November 1999,
Molecular pharmacology,
P Robberecht, and
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September 2000,
Pharmacology,
P Robberecht, and
M Delhaye, and
G Taton, and
P De Neef, and
M Waelbroeck, and
J M De Smet, and
J L Leclerc, and
P Chatelain, and
J Christophe
May 1988,
Journal of lipid research,
P Robberecht, and
M Delhaye, and
G Taton, and
P De Neef, and
M Waelbroeck, and
J M De Smet, and
J L Leclerc, and
P Chatelain, and
J Christophe
May 1988,
Investigative ophthalmology & visual science,
P Robberecht, and
M Delhaye, and
G Taton, and
P De Neef, and
M Waelbroeck, and
J M De Smet, and
J L Leclerc, and
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November 1996,
The American journal of physiology,
P Robberecht, and
M Delhaye, and
G Taton, and
P De Neef, and
M Waelbroeck, and
J M De Smet, and
J L Leclerc, and
P Chatelain, and
J Christophe
November 2003,
Naunyn-Schmiedeberg's archives of pharmacology,
