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In the past, pharmacokinetics of benzodiazepines have been extensively described. However, knowledge about relationships between their plasma levels and pharmacodynamic effects are scanty. Therefore, we investigated under several experimental conditions the disposition and the psychological response of the short acting midazolam (single dose 0,075 mg/kg i.v. and 15 mg po) and of the moderate long acting oxazepam (30 mg/die for 5 days). Psychological and psychomotoric effects were evaluated by analogue scales (sedation index), d-2 letter cancellation test, reaction time, critical flicker fusion frequency and adjective mood list. In general, good correlations were found between those tests and plasma levels, especially for midazolam. Analogue scales and reaction-time proved to be most useful in our "effect-kinetic" approach.
G Ziegler, and
L Ludwig, and
U Klotz
January 1982,
International journal of psychiatry in medicine,
G Ziegler, and
L Ludwig, and
U Klotz
November 1979,
The Journal of pharmacology and experimental therapeutics,
G Ziegler, and
L Ludwig, and
U Klotz
January 1978,
Arzneimittel-Forschung,
G Ziegler, and
L Ludwig, and
U Klotz
July 1973,
British medical journal,
G Ziegler, and
L Ludwig, and
U Klotz
February 2003,
Fertility and sterility,
G Ziegler, and
L Ludwig, and
U Klotz
January 1977,
The Journal of international medical research,
G Ziegler, and
L Ludwig, and
U Klotz
January 2022,
Bioengineered,
G Ziegler, and
L Ludwig, and
U Klotz
October 2002,
Fundamental & clinical pharmacology,
G Ziegler, and
L Ludwig, and
U Klotz
January 1972,
Padiatrie und Padologie,
G Ziegler, and
L Ludwig, and
U Klotz
March 1986,
The Journal of endocrinology,
