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We have compared the effects of equimolar doses of intravenous somatostatin-28 (SS-28) and somatostatin-14 (SS-14) (250 micrograms and 125 micrograms, respectively) on the secretion of pancreatic polypeptide (PP), glucagon and insulin evoked by a protein-rich meal in normal subjects. Both peptides reduced the fasting plasma levels of these hormones and completely abolished their responses to the alimentary stimulus; in addition, they caused an early decrease of plasma glucose followed by a hyperglycemic phase. As compared to SS-14, SS-28 elicited a longer-lasting inhibition of PP and insulin secretion and displayed greater hypo- and hyperglycemic effects. A somatostatin-like component, similar to SS-28, has been identified in pancreatic extracts as well as in peripheral plasma. Thus, it might be hypothesized that this peptide plays a role in the control of pancreatic hormone release.
J Marco, and
I Correas, and
M A Zulueta, and
E Vincent, and
D H Coy, and
A M Comaru-Schally, and
A V Schally, and
M D Rodríguez-Arnao, and
A Gómez-Pan
September 1982,
Diabete & metabolisme,
J Marco, and
I Correas, and
M A Zulueta, and
E Vincent, and
D H Coy, and
A M Comaru-Schally, and
A V Schally, and
M D Rodríguez-Arnao, and
A Gómez-Pan
September 1977,
Life sciences,
J Marco, and
I Correas, and
M A Zulueta, and
E Vincent, and
D H Coy, and
A M Comaru-Schally, and
A V Schally, and
M D Rodríguez-Arnao, and
A Gómez-Pan
January 1979,
Diabetes,
J Marco, and
I Correas, and
M A Zulueta, and
E Vincent, and
D H Coy, and
A M Comaru-Schally, and
A V Schally, and
M D Rodríguez-Arnao, and
A Gómez-Pan
February 2002,
European journal of endocrinology,
J Marco, and
I Correas, and
M A Zulueta, and
E Vincent, and
D H Coy, and
A M Comaru-Schally, and
A V Schally, and
M D Rodríguez-Arnao, and
A Gómez-Pan
September 1979,
Life sciences,
J Marco, and
I Correas, and
M A Zulueta, and
E Vincent, and
D H Coy, and
A M Comaru-Schally, and
A V Schally, and
M D Rodríguez-Arnao, and
A Gómez-Pan
January 1985,
European journal of clinical pharmacology,
J Marco, and
I Correas, and
M A Zulueta, and
E Vincent, and
D H Coy, and
A M Comaru-Schally, and
A V Schally, and
M D Rodríguez-Arnao, and
A Gómez-Pan
May 1977,
Diabetes,
J Marco, and
I Correas, and
M A Zulueta, and
E Vincent, and
D H Coy, and
A M Comaru-Schally, and
A V Schally, and
M D Rodríguez-Arnao, and
A Gómez-Pan
May 1981,
The Journal of clinical endocrinology and metabolism,
J Marco, and
I Correas, and
M A Zulueta, and
E Vincent, and
D H Coy, and
A M Comaru-Schally, and
A V Schally, and
M D Rodríguez-Arnao, and
A Gómez-Pan
January 1996,
Acta physiologica Hungarica,
J Marco, and
I Correas, and
M A Zulueta, and
E Vincent, and
D H Coy, and
A M Comaru-Schally, and
A V Schally, and
M D Rodríguez-Arnao, and
A Gómez-Pan
September 1975,
The Journal of clinical endocrinology and metabolism,
