BIOMAT Database Logo BIOMAT Database Logo

Inhibition of glucose-induced insulin secretion by somatostatin in goats. 1983

M A Maglad, and I A Wasfi, and S E Adam

Somatostatin inhibited glucose-induced insulin secretion in intact goats. The duration of the inhibition was short (10 minutes) which suggests that somatostatin was rapidly metabolised. The inhibitory effect of somatostatin was followed by a recovery period during which high levels of insulin were attained. These higher concentrations of insulin in the 30 to 60 minutes after somatostatin infusion, were accompanied by lowered free fatty acid and beta-hydroxybutyrate concentrations. It is suggested that the effects of somatostatin on these metabolites is brought about by modulation of insulin secretion and not by a direct effect of somatostatin on target tissues.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D003864 Depression, Chemical The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical. Chemical Depression,Chemical Depressions,Depressions, Chemical
D005230 Fatty Acids, Nonesterified FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form. Fatty Acids, Free,Free Fatty Acid,Free Fatty Acids,NEFA,Acid, Free Fatty,Acids, Free Fatty,Acids, Nonesterified Fatty,Fatty Acid, Free,Nonesterified Fatty Acids
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D006041 Goats Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP. Capra,Capras,Goat
D006885 Hydroxybutyrates Salts and esters of hydroxybutyric acid. Hydroxybutyric Acid Derivatives,Hydroxybutyric Acids,Acid Derivatives, Hydroxybutyric
D000078790 Insulin Secretion Production and release of insulin from PANCREATIC BETA CELLS that primarily occurs in response to elevated BLOOD GLUCOSE levels. Secretion, Insulin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013004 Somatostatin A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal. Cyclic Somatostatin,Somatostatin-14,Somatotropin Release-Inhibiting Hormone,SRIH-14,Somatofalk,Somatostatin, Cyclic,Somatotropin Release-Inhibiting Factor,Stilamin,Somatostatin 14,Somatotropin Release Inhibiting Factor,Somatotropin Release Inhibiting Hormone

Related Publications

M A Maglad, and I A Wasfi, and S E Adam
Proportional inhibition of glucose-induced insulin release by somatostatin.
December 1980, Metabolism: clinical and experimental,
M A Maglad, and I A Wasfi, and S E Adam
Inhibition of insulin secretion by somatostatin.
December 1973, Lancet (London, England),
M A Maglad, and I A Wasfi, and S E Adam
Glucose-induced inhibition of insulin secretion.
March 2014, Acta physiologica (Oxford, England),
M A Maglad, and I A Wasfi, and S E Adam
Inhibition of insulin secretion in vitro by somatostatin.
December 1974, Revista espanola de fisiologia,
M A Maglad, and I A Wasfi, and S E Adam
[INSULIN SECRETION IN VITRO. I. INHIBITION OF GLUCOSE-INDUCED INSULIN RELEASE BY INSULIN].
February 1965, Klinische Wochenschrift,
M A Maglad, and I A Wasfi, and S E Adam
Direct inhibition of insulin secretion by synthetic somatostatin.
June 1974, Biochemical and biophysical research communications,
M A Maglad, and I A Wasfi, and S E Adam
[Insulin secretion in vitro. II. Inhibition of glucose induced insulin release by diazoxide].
December 1966, Diabetologia,
M A Maglad, and I A Wasfi, and S E Adam
Inhibition of glucose-induced insulin secretion by intravenous colchicine in man.
December 1979, Metabolism: clinical and experimental,
M A Maglad, and I A Wasfi, and S E Adam
Reversal of somatostatin inhibition of insulin secretion by calcium.
October 1974, Biochemical and biophysical research communications,
M A Maglad, and I A Wasfi, and S E Adam
Somatostatin inhibition of insulin secretion in insulin-producing tumors.
June 1976, Metabolism: clinical and experimental,
Copied contents to your clipboard!