Biomaterial Database

[Comparison of the clinical effects of vecuronium and pancuronium bromide in general surgery]. 1983

M L Tannières-Ruffié, and G Vourc'h

50 patients selected at random were given vecuronium (group A) or pancuronium bromide (group B) at an initial dose of 0.05 mg X kg-1, followed by repeat injections of 0.0125 mg X kg-1. 34 other patients, separated in two groups: group C (vecuronium) and group D (pancuronium), received stronger doses of both drugs: 0.07 mg X kg-1 initially, followed by 0.022 mg X kg-1 repeat injections. The four groups were anaesthetized according to the same protocol; the patients underwent gastrointestinal and gynaecological surgery, lasting 122 +/- 50 min. The results showed that the time of onset and the duration of action of vecuronium were shorter, and that increasing the dose did not increase significantly the duration of action of these repeat doses: time of onset: 104 +/- 42 s (group A), 205 +/- 36 s (group B), 96 +/- 23 s (group C), 255 +/- 36 s (group D); duration of action: 19 +/- 6 min (group A), 36 +/- 6 min (group B), 24 +/- 7 min (group C), 43 +/- 13 min (group D); mean time between doses: 26 +/- 10 min (group A), 55 +/- 5 min (group B), 33 +/- 7 min (group C), 49 +/- 3 min (group D). The degree of muscle relaxation was always satisfactory in the four groups. Decurarization appeared to be particularly sudden with vecuronium. Neither an abnormally prolonged duration of action, nor any haemodynamic effect, nor any signs of histamine release were seen.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009126	Muscle Relaxation	That phase of a muscle twitch during which a muscle returns to a resting position.	Muscle Relaxations,Relaxation, Muscle,Relaxations, Muscle
D010197	Pancuronium	A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release.	Pancuronium Bromide,Pancuronium Curamed,Pancuronium Organon,Pavulon,Bromide, Pancuronium
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D003473	Neuromuscular Nondepolarizing Agents	Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.	Curare-Like Agents,Curariform Drugs,Muscle Relaxants, Non-Depolarizing,Neuromuscular Blocking Agents, Competitive,Nondepolarizing Blockers,Agents, Curare-Like,Agents, Neuromuscular Nondepolarizing,Blockers, Nondepolarizing,Curare Like Agents,Drugs, Curariform,Muscle Relaxants, Non Depolarizing,Non-Depolarizing Muscle Relaxants,Nondepolarizing Agents, Neuromuscular
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults