-transparent.png){kind=logo}
The strains of mice, C57BL/6J, DBA/2J, and B6D2F1/J, have been used as models to study the mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The distribution, excretion, and metabolism of this compound was studied in male C57BL/6J, DBA/2J, and B6D2F1/J mice following the intraperitoneal administration of radiolabeled TCDD at a dose of 10 micrograms/kg. In all strains, the liver and adipose tissue were the major sites for the accumulation of 3H-TCDD, with more 3H-TCDD being distributed to the livers of the C57BL/6J and B6D2F1/J strains as compared to the DBA/2J strain. While in all strains the feces were the major route of elimination, the total amount of 3H-TCDD-derived radioactivity excreted in the feces amounted to approximately 72% of the original dose in the C57BL/6J and B6D2F1/J strains whereas this was only 54% in the DBA/2J strain. The half-lives for the cumulative excretion of radioactivity in the feces were similar in all strains. The half-life for the excretion of radioactivity in the urine was considerably greater in the DBA/2J strain as compared to the C57BL/6J and B6D2F1/J strains. The estimated half-lives for the total cumulative excretion of 3H-TCDD-derived radioactivity by all routes was 11.0, 24.4, and 12.6 days for the C57BL/6J, DBA/2J, and B6D2F1/J strains, respectively. Greater than 85% of the total radioactivity excreted in urine, bile, and feces from all three mouse strains was present as metabolites of TCDD.
T A Gasiewicz, and
L E Geiger, and
G Rucci, and
R A Neal
April 1991,
Journal of toxicology and environmental health,
T A Gasiewicz, and
L E Geiger, and
G Rucci, and
R A Neal
March 1985,
Toxicology and applied pharmacology,
T A Gasiewicz, and
L E Geiger, and
G Rucci, and
R A Neal
July 1988,
Toxicology letters,
T A Gasiewicz, and
L E Geiger, and
G Rucci, and
R A Neal
July 1981,
Toxicology and applied pharmacology,
T A Gasiewicz, and
L E Geiger, and
G Rucci, and
R A Neal
March 1995,
Toxicology and applied pharmacology,
T A Gasiewicz, and
L E Geiger, and
G Rucci, and
R A Neal
November 1989,
Biochemical pharmacology,
T A Gasiewicz, and
L E Geiger, and
G Rucci, and
R A Neal
June 2011,
Molecular bioSystems,
T A Gasiewicz, and
L E Geiger, and
G Rucci, and
R A Neal
October 1979,
The Journal of biological chemistry,
T A Gasiewicz, and
L E Geiger, and
G Rucci, and
R A Neal
January 1992,
Drug metabolism and disposition: the biological fate of chemicals,
T A Gasiewicz, and
L E Geiger, and
G Rucci, and
R A Neal
January 1996,
Archives of toxicology,
